Based on the viewpoint of "sweat pore-

qi

and liquid-kidney collaterals"， it is believed that children's nephrotic syndrome is caused by the core mechanism of sweat pore constraint and closure，

qi

and liquid imbalance， and kidney collaterals impairment， and it is proposed that the treatment principle is to nourish the sweat pore， regulate

qi

and fluid， and supplement the kidney and unblock the collaterals. In clinic， guided by sequential therapy and according to the different disease mechanism characteristics of the four stages， including early stage of the disease， hormone induction stage， hormone reduction stage， hormone maintenance stage， the staged dynamic identification and treatment was applied. For early stage of the disease with edema due to

yang

deficiency， modified

Zhenwu Decoction

（真武汤） was applied to warm

yang

and drain water； for hormone induction stage with

yin

deficiency resulting in effulgent fire， modified

Zhibai Dihuang Pill

（知柏地黄丸） plus

Erzhi Pill

（二至丸） was used to enrich

yin

and reduce fire； for hormone reduction stage with

qi

and

yin

deficiency， modified

Shenqi Dihuang Decoction

（参芪地黄汤） was used to boost

qi

and nourish

yin

； for hormone maintenance stage， modified

Shenqi Pill

（肾气丸） was used to supplement

yin

and

yang

. Meanwhile， the treatment also attaches importance to the combination of vine-based or worm medicinals to dredge collaterals， so as to providing ideas for clinical treatment.