It is believed that psoriasis with anxiety and depression presents the pathogenesis of "depression-blood-spirit"， with

qi

depression as the initiating factor， and that the disease mechanism is understood from three aspects， including "

qi

depression transforming into fire， blood stasis disturbing the spirit"， "depressed fire consuming

yin

， causing blood dryness and spirit agitation"， "

qi

stagnation leading to blood stasis， resulting in obstructed channels and spirit depression". The treatment proposes three methods， firstly， cooling blood and resolving depression， secondly， nourishing blood and soothing depression， and thirdly， activating blood and regulating depression， which applies prescriptions as modified

Liangxue Huoxue Decoction

（凉血活血汤） combined with Zhiqiao （

Poncirus trifoliata

）， Foshou （

Citrus medica

）， and Lianqiaoxin （Forsythia suspensa） for cooling blood and resolving depression； modified

Yangxue Jiedu Decoction

（养血解毒汤） combined with Baishao （

Paeonia lactiflora Pall

）， Zhenzhumu （

Margaritifera Concha

）， and calcined Muli （

Ostreidae

） for nourishing blood and soothing depression； and modif

ied

Huoxue Sanyu Decoction

（活血散瘀汤） combined with Yujin （

Curcuma aromatica

） and Hehuanpi （

Albiziae Cortex

） for activating blood and regulating depression. These three methods integrate the "depression-blood-spirit" pathogenesis to achieve harmony of body and spirit by clearing blood heat， nourishing

yin

and blood， and removing blood stasis， complemented with medicinals that soothing the liver， calming the spirit， and regulating depression.