CAI Yongyuan,YAN Zhaoqi,LIU Zhiming,et al.Pathogenesis and Treatment of Sick Sinus Syndrome from the Perspective of "Kidney-Heart-Meridians"[J].Journal of Traditional Chinese Medicine,2025,66(14):1450-1455.
CAI Yongyuan,YAN Zhaoqi,LIU Zhiming,et al.Pathogenesis and Treatment of Sick Sinus Syndrome from the Perspective of "Kidney-Heart-Meridians"[J].Journal of Traditional Chinese Medicine,2025,66(14):1450-1455.DOI: 10.13288/j.11-2166/r.2025.14.008.
Pathogenesis and Treatment of Sick Sinus Syndrome from the Perspective of "Kidney-Heart-Meridians"
From the perspective of "kidney-heart-meridians", this paper explores the pathogenesis and treatment strategies for sick sinus syndrome (SSS). The author proposes that the root cause lies in kidney essence deficiency and failure of source
qi
generation. The key pathogenic mechanisms include
qi
sinking with cold generation and constrained heart
yang
. The chronic progression is attributed to impaired transformation of body fluids and blood, leading to stagnation and obstruction of the meridians. Phlegm retention and blood stasis obstructing the heart meridians are considered major factors in disease aggravation. Accordingly, the core treatment principles are to nourish the kidneys and restore source
qi
, tonify the heart and regulate the meridians. Supplementing
qi
, lifting sinking, soothing constraint, and promoting
yang
are employed to halt disease progression, while warming and enriching body fluids and blood aim to harmonize and unblock the meridians to improve prognosis. Strategies such as resolving phlegm, relieving obstruction, activating blood, and dispersing nodules are applied to prevent deterioration. This provides a reference framework for the clinical management of SSS.
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references
TAKASE B , IKEDA T , SHIMIZU W , et al . JCS/JHRS 2022 guideline on diagnosis and risk assessment of arrhythmia [J]. Circ J , 2024 , 88 ( 9 ): 1509 - 1595 .
KHANNA S , SREEDHARAN R , TROMBETTA C , et al . Sick sinus syndrome: sinus node dysfunction in the elderly [J]. Anesthesiology , 2020 , 132 ( 2 ): 377 - 378 .
HAMEED I , NUSRAT K , FARHAN SH , et al . Understanding disparities in cardiovascular death rates among older adults with sick sinus syndrome in the US [J]. Ann Med Surg (Lond) , 2024 , 86 ( 10 ): 5973 - 5979 .
ÇINIER G , HASEEB S , BAZOUKIS G , et al . Evaluation and management of asymptomatic bradyarrhythmias [J]. Curr Cardiol Rev , 2021 , 17 ( 1 ): 60 - 67 .
MANOJ P , KIM JA , KIM S , et al . Sinus node dysfunction: current understanding and future directions [J]. Am J Physiol Heart Circ Physiol , 2023 , 324 ( 3 ): H259 - H278 .
ZHAO F , XU K , ZHOU Z , et al . Morphometric CT angiographic study of the SSS and its adjacent structures: a comparative analysis between elderly and nonelderly individuals of a Han Chinese population [J]. Heliyon , 2023 , 10 ( 1 ): e23609 .
ORJI R , MARKSON F , ILELABOYE A , et al . Pulmonary hypertension is associated with worse outcomes in patients hospitalized for sick sinus syndrome [J]. J Innov Card Rhythm Manag , 2023 , 14 ( 10 ): 5622 - 5628 .
CHANG X , LI Y , LIU J , et al . β-tubulin contributes to tongyang huoxue decoction-induced protection against hypoxia/reoxygenation-induced injury of sinoatrial node cells through sirt1-mediated regulation of mitochondrial quality surveillance [J]. Phytomedicine , 2023 , 108 ( 1 ): 154502 .
CHEN M , WU Q . Roles and mechanisms of natural drugs on sinus node dysfunction [J]. Biomed Pharmacother , 2023 , 164 ( 8 ): 114777 .
LITVIŇUKOVÁ M , TALAVERA-LÓPEZ C , MAATZ H , et al . Cells of the adult human heart [J]. Nature , 2020 , 588 ( 7838 ): 466 - 472 .
CHEN L , HUA K , ZHANG N , et al . Multifaceted spatial and functional zonation of cardiac cells in adult human heart [J]. Circulation , 2022 , 145 ( 4 ): 315 - 318 .
THOROLFSDOTTIR RB , SVEINBJORNSSON G , AEGISDOTTIR HM , et al . Genetic insight into sick sinus syndrome [J]. Eur Heart J , 2021 , 42 ( 20 ): 1959 - 1971 .
DING Y , LANG D , YAN J , et al . A phenotype-based forward genetic screen identifies dnajb6 as a sick sinus syndrome gene [J]. Elife , 2022 , 18 ( 11 ): e77327 .
VAN DER MAAREL LE , POSTMA AV , CHRISTOFFELS VM . Genetics of sinoatrial node function and heart rate disorders [J]. Dis Model Mech , 2023 , 16 ( 5 ): dmm050101 .
YU Z , TANG PL , WANG J , et al . Mutations in hnrnpa1 cause congenital heart defects [J]. JCI Insight , 2018 , 3 ( 2 ): e98555 .
AI-OTHMAN S , BOYETT MR , MORRIS GM , et al . Symptomatic bradyarrhythmias in the athlete-underlying mechanisms and treatments [J]. Heart Rhythm , 2024 , 21 ( 8 ): 1415 - 1427 .
WU Q , CHEN Y , ZHOU Y , et al . Reliability, validity, and sensitivity of short-form 36 health survey (SF-36) in patients with sick sinus syndrome [J]. Medicine (Baltimore) , 2023 , 102 ( 24 ): e33979 .
JARIWALA P , GUDE D , KULKARNI GP , et al . Sino-atrial nodal artery occlusion causing acute sinus node dysfunction after percutaneous coronary intervention: case report and systematic review [J]. Pacing Clin Electrophysiol , 2024 , 47 ( 8 ): 1038 - 1048 .
CHURYLA A , MCCARTHY PM , KRUSE J , et al . Concomitant ablation of atrial fibrillation: new pacemakers and early rhythm recovery [J]. J Thorac Cardiovasc Surg , 2024 , 168 ( 6 ): 1677 - 1685 .
DI MAMBRO C , CALVIERI C , SILVETTI MS , et al . Bradyarrhythmias in repaired atrioventricular septal defects: single-center experience based on 34 years of follow-up of 522 patients [J]. Pediatr Cardiol , 2018 , 39 ( 8 ): 1590 - 1597 .
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