TENG Zhengwen,LI Nan,ZHANG Sai,et al.Pathogenesis and Treatment of Atopic Dermatitis from the Theory of Pathogens Intruding Eight Weak Areas[J].Journal of Traditional Chinese Medicine,2025,66(15):1548-1552.
TENG Zhengwen,LI Nan,ZHANG Sai,et al.Pathogenesis and Treatment of Atopic Dermatitis from the Theory of Pathogens Intruding Eight Weak Areas[J].Journal of Traditional Chinese Medicine,2025,66(15):1548-1552.DOI: 10.13288/j.11-2166/r.2025.15.007.
Pathogenesis and Treatment of Atopic Dermatitis from the Theory of Pathogens Intruding Eight Weak Areas
(《黄帝内经》), combined with the typical rash manifestations of atopic dermatitis, it is believed that atopic dermatitis is mostly deficiency-excess complex, and that pathogens intruding eight weak areas are the core of its pathogenesis. The external cause is exterior deficiencies, with heat, wind, dampness and other pathogenic
qi
attacking. The heart, lungs, kidneys out of balance, and excess pathogen are the internal cause, in which fire constraint and excessive heat are the basis of the disease, the wind invading leads to the progress of t
he changes, dampness obstructing channels and colla-terals make the condition persistent. Internal and external pathogens combination and retention result to the course of the disease lingering and difficult to cure. The internal treatment is to regulate
zang
-
fu
organs, and the formula could use self-prescribed modified
Qingrun Tongluo Decoction
(清润通络汤), clearing heart and reducing fire in order to clear the heat and cool the blood, moistening lungs and generating metal to consolidate the exterior and dispel the wind, and nourishing kidneys and draining water to dispel the dampness and activate the collaterals. The external treatment applies maceration, fire acupuncture, wrapping to dredge the eight weak areas and regulate
ABUABARA K , YU AM , OKHOVAT JP , et al . The prevalence of atopic dermatitis beyond childhood: a systematic review and meta-analysis of longitudinal studies [J]. Allergy , 2018 , 73 ( 3 ): 696 - 704 .
LEE HH , PATEL KR , SINGAM V , et al . A systematic review and meta-analysis of the prevalence and phenotype of adult-onset atopic dermatitis [J]. J Am Acad Dermatol , 2019 , 80 ( 6 ): 1526 - 1532 .
FRAZIER W , BHARDWAJ N . Atopic dermatitis: diagnosis and treatment [J]. Am Fam physician , 2020 , 101 ( 10 ): 590 - 598 .
QUADRI M , LOTTI R , BONZANO L , et al . A novel multi-action emollient plus cream improves skin barrier function in patients with atopic dermatitis: in vitro and clinical evidence [J]. Skin Pharmacol Physiol , 2021 , 34 ( 1 ): 8 - 18 .
ZHOU J , SUN Z , WANG X , et al . Low-temperature cold plasma promotes wound healing by inhibiting skin inflammation and improving skin microbiome [J]. Front Bioeng Biotechnol , 2025 , 13 : 1511259 . doi: 10.3389/fbioe. 2025. 1511259 http://dx.doi.org/10.3389/fbioe.2025.1511259 .
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Effects of Modified Guomin Decoction (加味过敏煎) on Traditional Chinese Medicine Syndromes and Quality of Life in Patients with Mild to Moderate Atopic Dermatitis of Heart Fire and Spleen Deficiency Pattern:A Randomized,Double-Blind,Placebo-Controlled Trial
Lianling Formula (连苓方) Combined with Topical Tacrolimus for Atopic Dermatitis in Adolescents with Heart Fire and Spleen Deficiency Syndrome:A Randomized Controlled Trial
YE Jianzhou's Experience in Treating Atopic Dermatitis in Children with the Method of Regulating the Heart and Treating the Spirit
Study on the Effect of Fuhe Decoction (敷和汤) with Different Doses of Suanzaoren (Ziziphus jujuba) on IgE Levels and Intestinal Flora in Atopic Dermatitis Model Mice
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