The Effects of Tai Chi Training on Bone Density，Bone Turnover Markers，and Heart Rate Variability in High-Risk Osteoporosis Population

LIN Jiaming; LI Chao; ZHAO Wei; ZHOU Jun; CHEN Xiaoying; XI Xiangyu; HE Haijun; MI Baohong; CHEN Yuefeng; CHEN Weiheng

doi:10.13288/j.11-2166/r.2025.15.010

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The Effects of Tai Chi Training on Bone Density，Bone Turnover Markers，and Heart Rate Variability in High-Risk Osteoporosis Population

更新时间：2025-07-31

- The Effects of Tai Chi Training on Bone Density，Bone Turnover Markers，and Heart Rate Variability in High-Risk Osteoporosis Population
- Journal of Traditional Chinese Medicine Vol. 66, Issue 15, Pages: 1566-1571(2025)
- 作者机构：
  
  1.北京中医药大学第三附属医院，北京市朝阳区安定门外小关街51号，100029
  2.中医骨伤治疗与运动康复智能化教育部工程研究中心
  3.国家奥林匹克体育中心
  4.四川省宜宾市中医医院
  5.北京市西城区广外医院
  6.中国中医科学院望京医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2025.15.010
  CLC：
- Received：08 December 2024，
  
  Revised：2025-06-02，
  
  Published：02 August 2025
- 稿件说明：
移动端阅览
林嘉铭,李超,赵伟等.太极拳训练对骨质疏松症高风险人群骨密度、骨转换标志物及心率变异性的影响[J].中医杂志,2025,66(15):1566-1571.

LIN Jiaming,LI Chao,ZHAO Wei,et al.The Effects of Tai Chi Training on Bone Density，Bone Turnover Markers，and Heart Rate Variability in High-Risk Osteoporosis Population[J].Journal of Traditional Chinese Medicine,2025,66(15):1566-1571.
林嘉铭,李超,赵伟等.太极拳训练对骨质疏松症高风险人群骨密度、骨转换标志物及心率变异性的影响[J].中医杂志,2025,66(15):1566-1571. DOI： 10.13288/j.11-2166/r.2025.15.010.

LIN Jiaming,LI Chao,ZHAO Wei,et al.The Effects of Tai Chi Training on Bone Density，Bone Turnover Markers，and Heart Rate Variability in High-Risk Osteoporosis Population[J].Journal of Traditional Chinese Medicine,2025,66(15):1566-1571. DOI： 10.13288/j.11-2166/r.2025.15.010.

摘要

目的

研究太极拳训练对骨质疏松症高风险人群骨密度、骨转换标志物和心率变异性的影响，为骨质疏松症的早期防治提供依据。

方法

纳入骨质疏松症高风险人群66例，采用随机数字表法分为试验组与对照组各33例。对照组接受每周3次的骨质疏松症健康宣教，试验组在对照组基础上接受由教练指导的每周3次、每次40 min的太极拳训练，两组均干预12周。干预前后采用双能X线骨密度仪分别检测两组受试者腰椎L

、双侧股骨颈及双侧全髋骨密度；采用酶联免疫吸附法测定干预前后的骨转换标志物，包括Ⅰ型原胶原氨基端前肽（P1NP）、β-Ⅰ型胶原交联羧基端肽（β-CTX）。选取试验组中依从性良好的受试者7例，佩戴心率传感器后先后进行太极拳训练与指南推荐的步行活动各20 min，采集运动过程中的心率变异性（HRV），包括时域指标［正常窦性心搏间期的标准差（SDNN）、相邻RR间期差的均方根（RMSSD）］、

频域指标［低频功率（LF）、高频功率（HF）、低频/高频功率比值（LF/HF）］、非线性指标［近似熵（ApEn）、样本熵（SampEn）］。

结果

最终63例受试者纳入结果分析，其中试验组30例，对照组33例。干预后，试验组腰椎L

、双侧股骨颈、双侧全髋骨密度与干预前比较差异均无统计学意义（

＞0.05），对照组各部位骨密度均较干预前明显下降（

＜0.05）。干预前后两组P1NP、β-CTX差异均无统计学意义（

＞0.05）。相较于步行运动，太极拳锻炼中的LF降低，HF升高，LF/HF降低（

＜0.05）；时域指标、非线性指标两组间差异均无统计学意义（

＞0.05）。

结论

太极拳能够维持骨质疏松症高风险人群腰椎、股骨颈、全髋的骨密度，改善交感/副交感神经平衡，但对于骨转换标志物的改善不显著。

Abstract

Objective

To explore the effects of the Tai Chi training on bone density， bone turnover markers， and heart rate variability for people with high-risk osteoporosis， and to provide evidence for the prevention of osteoporosis at early stage.

Methods

Sixty-six cases of people with high risk of osteoporosis were included， and they were divided into 33 cases each in the intervention group and the control group using the random number table method. The control group received osteoporosis health education three times a week， and the intervention group received Tai Chi training under the guidance of a trainer three times a week for 40 mins each time on the basis of the control group， and both groups were intervened for 12 weeks. Dual-energy X-ray absorptiometry was used to measure the bone density of L

vertebrae， bilateral femoral necks and bilateral total hips in the two groups before and after the intervention； enzyme-linked immunosorbent assay was used to determine bone turnover markers before and after the intervention， including pro-collagen type Ⅰ pro-amino-terminal prepropyl peptide （P1NP） and β-collagen type Ⅰ cross-linking carboxy-terminal peptide （β-CTX）. Seven cases with good compliance in the intervention group were selected. After wearing the heart rate sensor， they successively performed Tai Chi training and walking activities recommended by

the guideline for 20 mins each， and the heart rate variability （HRV） during exercise was collected， including time-domain indexes such as standard deviation of normal sinus intervals （SDNN）， root-mean-square of the difference between adjacent RR intervals （RMSSD）， frequency-domain metrics such as low-frequency power （LF）， high-frequency power （HF）， and low-frequency/high-frequency power ratio （LF/HF）， as well as nonlinear metrics such as approximate entropy （ApEn）， sample entropy （SampEn）.

Results

Finally， 63 cases were included in the outcome analysis， including 30 cases in the intervention group and 33 cases in the control group. After the intervention， the differences of L

vertebrae， bone density of bilateral femoral neck and bilateral total hip in the intervention group were not statistically significant when compared with those before intervention （

＞0.05）， while the bone density of all parts of the control group decreased significantly compared with that before intervention （

＜0.05）， and the difference in the bone density of the L

vertebrae， bilateral femoral neck， and the right total hip before and after the intervention of the intervention group was smaller than that of the control group （

＜0.05）. The differences in P1NP and β-CTX between groups before and after intervention was not statistically significant （

＞0.05）. Compared with walking exercise， LF decreased， HF increased and LF/HF decreased during Tai Chi exercise （

＜0.05）； the time domain indexes and non-linear indexes between groups had no statistically significant difference （

＞0.05）.

Conclusion

Tai Chi exercise can maintain lumbar， hip， and femoral bone density and improve sympathetic/parasympathetic balance in people at high risk for osteoporosis， but cannot significantly improve bone turnover markers.

关键词

Keywords

references

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