Correlation Between Cardiovascular Events and Traditional Chinese Medicine Syndrome in Patients with Rheumatoid Arthritis：A Cross-Sectional Study

ZHANG Fuyuan; JIANG Quan; LI Jun; YANG Yuchen; MA Xieli; CHANG Tian; XIA Congmin; WANG Jian; GONG Xun

doi:10.13288/j.11-2166/r.2025.15.011

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Correlation Between Cardiovascular Events and Traditional Chinese Medicine Syndrome in Patients with Rheumatoid Arthritis：A Cross-Sectional Study

更新时间：2025-07-31

- Correlation Between Cardiovascular Events and Traditional Chinese Medicine Syndrome in Patients with Rheumatoid Arthritis：A Cross-Sectional Study
- Journal of Traditional Chinese Medicine Vol. 66, Issue 15, Pages: 1572-1578(2025)
- 作者机构：
  
  中国中医科学院广安门医院，北京市西城区北线阁5号，100053
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2025.15.011
  CLC：
- Received：08 January 2025，
  
  Revised：2025-05-22，
  
  Published：02 August 2025
- 稿件说明：
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张富渊,姜泉,李军等.类风湿关节炎心血管事件与中医证型相关性的多中心横断面临床研究[J].中医杂志,2025,66(15):1572-1578.

ZHANG Fuyuan,JIANG Quan,LI Jun,et al.Correlation Between Cardiovascular Events and Traditional Chinese Medicine Syndrome in Patients with Rheumatoid Arthritis：A Cross-Sectional Study[J].Journal of Traditional Chinese Medicine,2025,66(15):1572-1578.
张富渊,姜泉,李军等.类风湿关节炎心血管事件与中医证型相关性的多中心横断面临床研究[J].中医杂志,2025,66(15):1572-1578. DOI： 10.13288/j.11-2166/r.2025.15.011.

ZHANG Fuyuan,JIANG Quan,LI Jun,et al.Correlation Between Cardiovascular Events and Traditional Chinese Medicine Syndrome in Patients with Rheumatoid Arthritis：A Cross-Sectional Study[J].Journal of Traditional Chinese Medicine,2025,66(15):1572-1578. DOI： 10.13288/j.11-2166/r.2025.15.011.

摘要

目的

探讨类风湿关节炎心血管事件（RA-CEs）与中医证型的相关性。

方法

采用横断面研究，选取自全国122家中心共6713例类风湿关节炎（RA）患者，通过填写问卷调查，收集患者的姓名、性别、年龄、身高、体重、病程等一般资料信息；根据患者四诊信息辨证分为风湿痹阻证、寒湿痹阻证、湿热痹阻证、痰瘀痹阻证、瘀血阻络证、气血两虚证、肝肾不足证、气阴两虚证8种证型；根据心血管事件的发生情况分为发生组和未发生组；记录病情评估资料及实验室检查指标。组间差异性检验分析RA-CEs发生的可能危险因素，并采用二元Logistic回归分析中医证型与RA-CEs的相关性。

结果

6713例RA患者中发生组256例，未发生组6457例。两组患者在身高、性别、失眠、食欲、白细胞计数（WBC）、血红蛋白（

HGB）、血小板（PLT）、类风湿因子（RF）、抗环瓜氨酸抗体（CCP）、丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）、谷氨酰转移酶（GGT）、尿素（UREA）、肌酐（CREA）和空腹血糖（GLU）方面比较差异无统计学意义（

＞0.05）。两组患者的中医证型比较差异具有统计学意义（

＜0.05）。发生组患者的病程更长、体重及年龄更大，疾病活动度（DAS-28）评分、疼痛关节数（TJC）、肿胀关节数（SJC）、健康问卷评分（HAQ）评分、视觉模拟评分法（VAS）评分、心烦不安、疲乏症状更严重，红细胞沉降率（ESR）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、总胆固醇（TC）、D-二聚体（D-Dimer）更高，高密度脂蛋白胆固醇（HDL-C）更低（

＜0.05）。证型分布显示，湿热痹阻证在两组患者中均占比最高，且在发生组中占比更高。Logistic回归分析显示，RA-CEs发生与湿热痹阻证密切相关［

=5.937，95%

（4.434，7.949），

＜0.001］。

结论

RA-CEs的发生与中医证型相关，湿热痹阻证型发生心血管事件的概率是非湿热痹阻证的5.937倍。

Abstract

Objective

To explore the correlation between the occurrence of cardiovascular events in rheumatoid arthritis（RA） and traditional Chinese medicine（TCM） syndrome.

Methods

The cross-sectional study selected 6713 RA patients from 122 centres nationwide， in which general information such as name， gender， age， height， body weight， and course of disease were collected by completing a questionnaire； patients were classified into eight types of syndrome according to the information of their four examinations，i.e. wind-dampness obstruction syndrome， cold-dampness obstruction syndrome， dampness-heat obstruction syndrome， phlegm-stasis obstruction syndrome， stasis-blood obstructing collateral syndrome，

-blood deficiency syndrome， liver-kidney insufficiency syndrome， and

yin

deficiency syndrome. According to the occurrence of cardiovascular events， they were divided into the occurrence group and the non-occurrence group， and the condition assessment data and laboratory examination indexes were recorded. The test of difference between groups was used to analyse the possible risk factors for the occurrence of RA cardiovascular events， and binary logistic regression was used to analyse the correlation between TCM syndrome

s and RA cardiovascular events.

Results

A total of 6713 RA patients were included， including 256 cases in occurrence group and 6457 in non-occurrence group. There was no statistically significant difference between groups in terms of height， gender， insomnia， appetite， white blood cell（WBC）， hemoglobin（HGB）， platelets（PLT）， rheumatoid factor（RF）， anti-cyclic peptide containing citrulline（CCP）， alanine aminotransferase（ALT）， aspartate aminotransferase（AST）， γ-glutamyl transpeptidase（GGT）， urea creatinine（CREA）， and glucose（GLU）（

＞0.05）. The TCM syndromes between groups showed significant statistic differences（

＜0.05）. Patients in occurrence group had longer disease duration， heavier body weight， and older age； more severe conditions such as disease activity（DAS-28）， number of painful joints（TJC）， number of swollen joints（SJC）， health questionnaire scores（HAQ）， visual analog scores（VAS）， restlessness， and fatigue； higher blood sedimentation rate（ESR）， low-density lipoprotein（LDL-C）， triglyceride（TG）， total cholesterol（TC）， D-Dimer， and lower high-density lipoprotein（HDL-C）（

＜0.05）. The distribution of syndrome types showed that dampness-heat obstruction syndrome accounted for the largest proportion of patients in both groups and was higher in RA cardiovascular events. Logistic regression analysis showed that the occurrence of RA cardiovascular events was strongly associated with dampness-heat obstruction syndrome［

=5.937， 95%

（4.434， 7.949），

＜0.001］.

Conclusion

The occurrence of RA cardiovascular events were associated with TCM syndromes， and the probability of cardiovascular events in the RA patients with dampness-heat obstruction syndrome was 5.937 times higher than patients with other TCM syndromes.

关键词

Keywords

references

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