OUYANG Guishu,LI Guangyu,TANG Xianping,et al.Treating Adult-onset Still's Disease Based on the Theory of Latent Pathogens in Yin (阴)Level[J].Journal of Traditional Chinese Medicine,2025,66(15):1604-1609.
OUYANG Guishu,LI Guangyu,TANG Xianping,et al.Treating Adult-onset Still's Disease Based on the Theory of Latent Pathogens in Yin (阴)Level[J].Journal of Traditional Chinese Medicine,2025,66(15):1604-1609.DOI: 10.13288/j.11-2166/r.2025.15.015.
Treating Adult-onset Still's Disease Based on the Theory of Latent Pathogens in Yin (阴)Level
Guided by the theory of latent pathogens, it is believed that the basic pathogenesis of adult-onset Still's disease is the latent pathogens in the deep
yin
level. The onset of the disease is fundamentally characterized by the deficiency of both
qi
and
yin
as the root, with dampness, heat, phlegm, and blood stasis as the branch, which triggered by intruding pathogens activate the latent pathogens in
yin
level. The treatment focuses on nourishing
yin
and dispersing heat as the key therapeutic method. It is proposed that clearing and resolving dampness-heat, expelling pathogens outward, di
spersing the latent pathogens, reinforcing healthy
qi
and consolidating the root, boosting
qi
and nourishing
yin
as treatment idea. In clinic,
Qinghao Biejia Decoction
(青蒿鳖甲汤) could be used as the basic formula, and modified with characteristic herb pairs such as Qinghao (
Artemisia annua
) - Digupi (
Lycium chinense
) to enrich
yin
and clear heat, and enforce the power of clearing deficient heat; Biejia (
Lawsonia inermis
) - Xuchangqing (
Vincetoxicum mukdenense
) to enrich
yin
and activate blood, unblock the collaterals and dissipate masses; Duhuo (
Angelica biserrata
) - Mudanpi (
Paeonia × suffruticosa
) to dispel wind and activate blood, resolve dampness and unblock the collaterals, so as to clear and warm simultaneously, and regulate
qi
and blood at the same time; and Chuanshanlong (
Dioscorea nipponica
) - Difuzi (
Bassia scoparia
) to dissolve stasis and dispel phlegm, explore and dispel latent pathogens.
EFTHIMIOU P , KONTZIAS A , HUR P , et al . Adult-onset Still's disease in focus: Clinical manifestations, diagnosis, treatment, and unmet needs in the era of targeted therapies [J]. Semin Arthritis Rheum , 2021 , 51 ( 4 ): 858 - 874 .
HWANG IS , KIM JE , LEE YJ , et al . Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury [J]. Int J Mol Med , 2013 , 31 ( 4 ): 888 - 898 .
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Related Institution
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