FANG Dingya's Experience in Staged Differentiation and Treatment of Connective Tissue Disease with Immune Thrombocytopenia Based on the Theory of Collateral Disease

LI Zhuanzhuan; TANG Jinyang; WANG Xin; DONG Fei; ZHOU Caiyun; YE Yuqing; FAN Bingbing; MA Fang

doi:10.13288/j.11-2166/r.2025.17.004

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FANG Dingya's Experience in Staged Differentiation and Treatment of Connective Tissue Disease with Immune Thrombocytopenia Based on the Theory of Collateral Disease

更新时间：2025-08-28

- FANG Dingya's Experience in Staged Differentiation and Treatment of Connective Tissue Disease with Immune Thrombocytopenia Based on the Theory of Collateral Disease
- Journal of Traditional Chinese Medicine Vol. 66, Issue 17, Pages: 1754-1758(2025)
- 作者机构：
  
  1.天津中医药大学，天津市静海区团泊新城西区鄱阳湖路10号，301617
  2.中国中医科学院西苑医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2025.17.004
  CLC：
- Received：17 October 2024，
  
  Revised：2025-06-05，
  
  Published：02 September 2025
- 稿件说明：
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李转转,唐今扬,王鑫等.房定亚基于络病理论分期论治结缔组织病伴免疫性血小板减少症经验[J].中医杂志,2025,66(17):1754-1758.

LI Zhuanzhuan,TANG Jinyang,WANG Xin,et al.FANG Dingya's Experience in Staged Differentiation and Treatment of Connective Tissue Disease with Immune Thrombocytopenia Based on the Theory of Collateral Disease[J].Journal of Traditional Chinese Medicine,2025,66(17):1754-1758.
李转转,唐今扬,王鑫等.房定亚基于络病理论分期论治结缔组织病伴免疫性血小板减少症经验[J].中医杂志,2025,66(17):1754-1758. DOI： 10.13288/j.11-2166/r.2025.17.004.

LI Zhuanzhuan,TANG Jinyang,WANG Xin,et al.FANG Dingya's Experience in Staged Differentiation and Treatment of Connective Tissue Disease with Immune Thrombocytopenia Based on the Theory of Collateral Disease[J].Journal of Traditional Chinese Medicine,2025,66(17):1754-1758. DOI： 10.13288/j.11-2166/r.2025.17.004.

摘要

总结房定亚基于络病理论分期论治结缔组织病伴免疫性血小板减少症的经验。认为络脉受损是本病的基本病机，急性期以热毒伤络、血溢脉外为病机关键，治以清络解毒，凉血散血，方选犀角地黄汤加减；慢性期气血不充、络虚失荣，治宜益气养血，护脉通络，方用归脾汤化裁。久病入络，瘀结最深，非通不达，故化瘀通络法贯穿治疗全程。

Abstract

This paper is to summarize professor FANG Dingya's clinical experience in staged differentiation and treatment of connective tissue disease with immune thrombocytopenia （CTD-ITP） based on collateral disease theory. It is believed that the fundamental pathological feature is collateral vessel impairment. During the acute stage， the key pathogenesis lies in heat-toxin damaging collaterals， then blood extravasation outside the vessels， for which the treatment focuses on clearing collaterals and resolving toxins， cooling the blood and dissipating blood stasis， prescribing with modified

Xijiao Dihuang Decoction

（犀角地黄汤）. During the chronic stage， characterized by deficiency of

and blood， colla-terals failing to receive nourishment， the therapeutic principle shifts to tonifying

and nourishing blood， protecting vessels and dredging collaterals， prescribing with modified

Guipi Decoction

（归脾汤）. Considering that persistent illness penetrates deeply into collaterals leading to blood stasis accumulates， which cannot be resolved without dredging therapy， the stasis-dissolving and collateral-dredging method should be consistently applied throughout the entire treatment course.

关键词

Keywords

references

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