Latent Class and Latent Structure Analysis of Traditional Chinese Medicine Syndrome Distribution in 100 Cases of Children After Hematopoietic Stem Cell Transplantation

HUANG Baoyi; YI Lichen; LI Pinggan; XU Hua; HUANG Ke

doi:10.13288/j.11-2166/r.2025.17.009

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Latent Class and Latent Structure Analysis of Traditional Chinese Medicine Syndrome Distribution in 100 Cases of Children After Hematopoietic Stem Cell Transplantation

更新时间：2025-08-28

- Latent Class and Latent Structure Analysis of Traditional Chinese Medicine Syndrome Distribution in 100 Cases of Children After Hematopoietic Stem Cell Transplantation
  增强出版
- Journal of Traditional Chinese Medicine Vol. 66, Issue 17, Pages: 1783-1792(2025)
- 作者机构：
  
  1.广州中医药大学第一附属医院，广东省广州市白云区机场路16号，510405
  2.广东省中医临床研究院
  3.广州中医药大学
  4.中山大学孙逸仙纪念医院儿童医学中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2025.17.009
  CLC：
- Received：27 October 2024，
  
  Revised：2025-01-18，
  
  Published：02 September 2025
- 稿件说明：
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黄宝仪,易立琛,李平甘等.100例造血干细胞移植后患儿中医证候分布特点的潜在类别及隐结构分析[J].中医杂志,2025,66(17):1783-1792.

HUANG Baoyi,YI Lichen,LI Pinggan,et al.Latent Class and Latent Structure Analysis of Traditional Chinese Medicine Syndrome Distribution in 100 Cases of Children After Hematopoietic Stem Cell Transplantation[J].Journal of Traditional Chinese Medicine,2025,66(17):1783-1792.
黄宝仪,易立琛,李平甘等.100例造血干细胞移植后患儿中医证候分布特点的潜在类别及隐结构分析[J].中医杂志,2025,66(17):1783-1792. DOI： 10.13288/j.11-2166/r.2025.17.009.

HUANG Baoyi,YI Lichen,LI Pinggan,et al.Latent Class and Latent Structure Analysis of Traditional Chinese Medicine Syndrome Distribution in 100 Cases of Children After Hematopoietic Stem Cell Transplantation[J].Journal of Traditional Chinese Medicine,2025,66(17):1783-1792. DOI： 10.13288/j.11-2166/r.2025.17.009.

摘要

目的

探讨造血干细胞移植（HSCT）后患儿的中医证候特点，为其临床辨治提供参考。

方法

纳入HSCT后患儿100例，采集患儿基本信息和中医四诊信息。应用Mplus 8.3和Lantern 5.0软件分别进行潜在类别分析和隐结构分析，归纳儿童HSCT后中医证候特点。

结果

共纳入症状、体征69项，出现频次前5位的症状、体征依次为：舌质淡红（77次）、舌苔白（66次）、脉细（64次）、食欲不振（62次）、乏力（59次）。选择频次＞5的56项中医症状、体征进行潜在类别分析，得到潜在类别数为4的潜在模型，结合临床分析得出主要证候为气阴两虚证、脾肾两虚证、肺脾气虚证及阴虚夹湿证。将纳入的69项中医症状、体征进行隐结构分析，得到9个隐变量，结合中医理论及临床实际，将隐变量进行综合聚类得到5个证候，分别为肺脾气虚证、气阴两虚证、脾虚湿困证、脾肾两虚证和阴虚内热证及部分夹瘀。

结论

HSCT后患儿中医常见证候为气阴两虚证、脾虚湿困证、肺脾气虚证、脾肾两虚证、阴虚内热证、阴虚夹湿证及部分夹瘀，病位以脾、肺、肾为主，病性以虚为主，多虚实夹杂。

Abstract

Objective

To explore the characteristics of traditional Chinese medicine （TCM） syndromes in children after hematopoietic stem cell transplantation （HSCT） and provide a reference for clinical syndrome differentiation and treatment.

Methods

A total of 100 pediatric patients after HSCT were enrolled. Basic information and TCM four-diagnosis data were collected. Latent class analysis （LCA） and latent structure analysis （LSA） were performed using Mplus 8.3 and Lantern 5.0， respectively， to summarize the TCM syndrome characteristics in children after HSCT.

Results

A total of 69 symptoms and signs were included. The five most frequent symptoms/signs were pale-red tongue body （77 cases）， white tongue coating （66 cases）， thready pulse （64 cases）， poor appetite （62 cases）， and fatigue （59 cases）. Fifty-six TCM symptoms/signs with frequency ＞5 were subjected to LCA， resulting in a four-class latent model. Clinical interpretation identified the main syndromes as dual deficiency of

and

yin

， dual deficiency of the spleen and kidney， lung-spleen

deficiency， and

yin

deficiency with dampness. LSA of all 69 TCM symptoms/signs yielded nine latent variables. Based on TCM theory and clinical practice， these latent variables were clustered into five syndromes， lung-spleen

deficiency， dual deficiency of

and

yin

， spleen deficiency with dampness encumbrance， dual deficiency of the spleen and kidney， and

yin

deficiency with internal heat， partially accompanied by blood stasis.

Conclusion

Common TCM syndromes in children after HSCT include dual defic

iency of

and

yin

， spleen deficiency with dampness encumbrance， lung-spleen

deficiency， dual deficiency of the spleen and kidney，

yin

deficiency with internal heat，

yin

deficiency with dampness， and partial syndromes accompanied by blood stasis. The main affected organs are the spleen， lung， and kidney； deficiency is the predominant nature of disease， often accompanied by excess.

关键词

Keywords

references

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Related Institution

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