CHEN Hongli,REN Xuelei,YANG Liping,et al.Discussion on the Pathogenesis and Treatment of Idiopathic Membranous Nephropathy based on 'Minngyuan Sanjiao (三焦) System'[J].Journal of Traditional Chinese Medicine,2025,66(18):1887-1890.
CHEN Hongli,REN Xuelei,YANG Liping,et al.Discussion on the Pathogenesis and Treatment of Idiopathic Membranous Nephropathy based on 'Minngyuan Sanjiao (三焦) System'[J].Journal of Traditional Chinese Medicine,2025,66(18):1887-1890.DOI: 10.13288/j.11-2166/r.2025.18.006.
Discussion on the Pathogenesis and Treatment of Idiopathic Membranous Nephropathy based on 'MinngyuanSanjiao (三焦) System'
(命元三焦) system is a primordial life system composed of the mingmen (gate of vitality), original
qi
, and
sanjiao.
The system is centered on the vital gate, where the primordial
qi
is generated and transmitted through the
sanjiao
to the inside and outside of the body, thus regulating the activities of the
zang
-
fu
(脏腑) organs and channel meridians. Based on the system, it is believed that idiopathic membranous nephropathy (IMN) has its pathogenic foundation in the deficiency of
mingyuan
and insufficiency of the spleen and kidney. The core mechanism involves impaired
qi
transformation within
sanjiao
and the obstruction of the renal collaterals by phlegm, dampness, and stasis. and the decline of the
mingyuan
, the internal accumulation of the turbid toxin, and the damage to the kidney channels as the final regression. The clinical treatment of this disease should be warming and tonifying the vital gate and primordial
qi
supplemented by dredging and benefiting the
sanjiao
, and applying treatments such as activating blood circulation and removing blood stasis, dispelling phlegm and removing dampness, and draining turbidity and clearing up the channels for the different signs of blood stasis, phlegm and dampness, and turbidity and toxins, respectively.
HOFSTRA JM , FERVENZA FC , WETZELS JF . Treatment of idiopathic membranous nephropathy [J]. Nat Rev Nephrol , 2013 , 9 ( 8 ): 443 - 458 .
CHEN Y , DENG Y , NI Z , et al . Efficacy and safety of traditional Chinese medicine (Shenqi particle) for patients with idiopathic membranous nephropathy: a multicenter randomized controlled clinical trial [J]. Am J Kidney Dis , 2013 , 62 ( 6 ): 1068 - 1076 .