To summarize Professor WANG Xixing's clinical experience in treating advanced breast cancer with anxiety and depression from the perspective of

shaoyang

pivot. It is believed that the core pathogenesis of advanced breast cancer with anxiety and depression lies in the dysfunction of

shaoyang

pivot （referring to the imbalanced regulatory function of the

shaoyang

meridian system that governs the transportation and transformation of

qi

， blood， and body fluids）. This dysfunction can lead to abnormal circulation of

qi

， blood， and body fluids， as well as the intermingling of phlegm and blood stasis， which further promotes the spread and diffusion of cancer toxin. Meanwhile， it disturbs mental activity， resulting in a condition characterized by stagnation of cancer toxin and concurrent disorders of both the physical body and the spirit. Based on this pathogenesis， the basic therapeutic principles of harmonizing

shaoyang

， regulating the pivot to calm the spirit， and dissipating masses and resolving toxins are proposed. Clinically， the disease is classified into three syndromes for differentiation and treatment. For

shaoyang

pivot dysfunction syndrome， treatment should use self-prescribed

Chaiqin Hengshu Ningxin Decoction

（柴芩衡枢宁神汤）； for

sanjiao

pivot dysfunction syndrome， treatment should prescribe

Chaigui Tongshu Dashen Decoction

（柴归通

枢达神饮）； for gallbladder function disorder syndrome， treatment should apply

Wendan Qishu Shoushen Decoction

（温胆启枢守神汤）. Throughout the treatment process， the concept of "simultaneous treatment of cancer and depression" is implemented to smooth the

shaoyang

pivot， block the vicious cycle where cancer toxin and emotional abnormalities mutually reinforce each other.