The Pathogenic Evolution and Therapeutic Approaches of Rheumatoid Arthritis Complicated by Sarcopenia Based on the Theory of '<italic style="font-style: italic">Bi </italic>（痹） of both Body and Viscera'

ZHONG Shuai; JIANG Ping; ZHAO Xiaohu; LIU Yuan; TIAN Xuanhe

doi:10.13288/j.11-2166/r.2025.23.009

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The Pathogenic Evolution and Therapeutic Approaches of Rheumatoid Arthritis Complicated by Sarcopenia Based on the Theory of 'Bi （痹） of both Body and Viscera'

更新时间：2025-12-04

- The Pathogenic Evolution and Therapeutic Approaches of Rheumatoid Arthritis Complicated by Sarcopenia Based on the Theory of 'Bi （痹） of both Body and Viscera'
- Journal of Traditional Chinese Medicine Vol. 66, Issue 23, Pages: 2443-2446(2025)
- 作者机构：
  
  1.山东中医药大学第一临床医学院，山东省济南市历下区山师东路16-81号，250014
  2.山东中医药大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2025.23.009
  CLC：
- Received：12 September 2025，
  
  Revised：2025-10-20，
  
  Published：02 December 2025
- 稿件说明：
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钟帅,姜萍,赵啸虎等.运用“体脏合痹”理论探析类风湿关节炎并发肌少症的病机演化与辨治[J].中医杂志,2025,66(23):2443-2446.

ZHONG Shuai,JIANG Ping,ZHAO Xiaohu,et al.The Pathogenic Evolution and Therapeutic Approaches of Rheumatoid Arthritis Complicated by Sarcopenia Based on the Theory of 'Bi （痹） of both Body and Viscera'[J].Journal of Traditional Chinese Medicine,2025,66(23):2443-2446.
钟帅,姜萍,赵啸虎等.运用“体脏合痹”理论探析类风湿关节炎并发肌少症的病机演化与辨治[J].中医杂志,2025,66(23):2443-2446. DOI： 10.13288/j.11-2166/r.2025.23.009.

ZHONG Shuai,JIANG Ping,ZHAO Xiaohu,et al.The Pathogenic Evolution and Therapeutic Approaches of Rheumatoid Arthritis Complicated by Sarcopenia Based on the Theory of 'Bi （痹） of both Body and Viscera'[J].Journal of Traditional Chinese Medicine,2025,66(23):2443-2446. DOI： 10.13288/j.11-2166/r.2025.23.009.

摘要

基于体脏合痹理论，系统探讨类风湿关节炎（RA）并发肌少症的中医病机演化规律，提出“肌痹→脾痹→痿痹”的传变路径，认为营卫失和是贯穿始终的核心病机。并结合现代分子生物学研究，提出肿瘤坏死因子样弱凋亡诱导蛋白-成纤维细胞生长因子14（TWEAK-Fn14）轴介导的骨骼肌稳态失衡可能是该病机演化的物质基础。在此基础上，进一步提出“调补营卫、温阳行痹、以体养脏”与“运脾化浊、清热通痹、调脏安体”的中医治疗策略，强调体脏同治、防治结合，以此为RA并发肌少症的中医药防治提供理论依据与临床思路。

Abstract

Based on the theory of '

（痹） of both body and viscera'， this paper syste

matically discussed the pathogenic evolution of rheumatoid arthritis （RA） complicated by sarcopenia from the perspective of traditional Chinese medicine （TCM）. It is proposed that a transformation pathway is muscle

to spleen

and then atrophy

， and the core pathogenesis is diaharmony of

ying

（营） and

wei

（卫）. Combining modern molecular biology research， it is suggested that imbalances in skeletal muscle homeostasis mediated by the tumor necrosis factor-like weak inducer of apoptosis-ibroblast growth factor-inducible 14 （TWEAK-Fn14） axis may provide the material basis for the evolution of this disease. Furthermore， this authors proposed TCM treatment strategies， including "regulating and tonifying

ying

and

wei

， warming

yang

and moving

， nourishing the viscera by supporting the body"， and "promoting the spleen and resolving turbidity， clearing heat and promoting circulation， regulating the organs and calming the body". These strategies emphasize the simultaneous treatment of body and viscera， integrated prevention and treatment， so as to provide TCM theoretical foundation and clinical approaches for preventing and treating RA complicated by sarcopenia.

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Keywords

references

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The Pathogenic Evolution and Therapeutic Approaches of Rheumatoid Arthritis Complicated by Sarcopenia Based on the Theory of 'Bi （痹） of both Body and Viscera'

DOI：10.13288/j.11-2166/r.2025.23.009

摘要

Abstract

关键词

Keywords

references