Discussion on the Dynamic Pathogenesis of Coronary Heart Disease from the Perspective of "<italic style="font-style: italic">Qi</italic> Transporting in the Vessels，Blood Flowing in the Vessels，and the Vessels are the Pivotal"

LI Lanlan; PENG Han; GAO Jiaming; CHEN Yuanyuan; CAO Ce; ZHANG Xiaoqing; GUO Fan; XU Shujuan; GU Chenchen; LI Lei; ZHANG Junhua; FU Jianhua

doi:10.13288/j.11-2166/r.2025.24.015

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Discussion on the Dynamic Pathogenesis of Coronary Heart Disease from the Perspective of "Qi Transporting in the Vessels，Blood Flowing in the Vessels，and the Vessels are the Pivotal"

更新时间：2026-02-04

- Discussion on the Dynamic Pathogenesis of Coronary Heart Disease from the Perspective of "Qi Transporting in the Vessels，Blood Flowing in the Vessels，and the Vessels are the Pivotal"
- Journal of Traditional Chinese Medicine Vol. 66, Issue 24, Pages: 2603-2607(2025)
- 作者机构：
  
  1.中国中医科学院西苑医院，北京市海淀区西苑操场1号，100091
  2.天津中医药大学
  3.国家中医心血管病临床医学研究中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2025.24.015
  CLC：
- Received：25 April 2025，
  
  Revised：2025-10-10，
  
  Published：17 December 2025
- 稿件说明：
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李兰兰,彭涵,高佳明等.从气运于脉、血行于脉、脉为枢机探析冠心病的动态病机[J].中医杂志,2025,66(24):2603-2607.

LI Lanlan,PENG Han,GAO Jiaming,et al.Discussion on the Dynamic Pathogenesis of Coronary Heart Disease from the Perspective of "Qi Transporting in the Vessels，Blood Flowing in the Vessels，and the Vessels are the Pivotal"[J].Journal of Traditional Chinese Medicine,2025,66(24):2603-2607.
李兰兰,彭涵,高佳明等.从气运于脉、血行于脉、脉为枢机探析冠心病的动态病机[J].中医杂志,2025,66(24):2603-2607. DOI： 10.13288/j.11-2166/r.2025.24.015.

LI Lanlan,PENG Han,GAO Jiaming,et al.Discussion on the Dynamic Pathogenesis of Coronary Heart Disease from the Perspective of "Qi Transporting in the Vessels，Blood Flowing in the Vessels，and the Vessels are the Pivotal"[J].Journal of Traditional Chinese Medicine,2025,66(24):2603-2607. DOI： 10.13288/j.11-2166/r.2025.24.015.

摘要

基于中医气血理论，构建“气运于脉、血行于脉、脉为枢机”三维动态病机模型，指出脉是气血运行的关键枢纽，通畅时维持生理功能，失于约束则致病。并阐释冠心病动态病机演变规律，即功能失调期，情志等诱因致气机失常，气血输布滞缓，引发冠心病早期症状，以功能性失调为主；结构损伤期，脉道枢机调控失司，气血壅滞，痰瘀积聚，导致脉道结构损伤，病情复杂；多器官受累期，脉道失枢，气血逆乱，累及多脏，出现全身系统衰竭，预后凶险。在治疗策略上，根据不同阶段特点，提出调气、畅脉、活血三位一体的治疗原则，功能失调期调气血复脉枢、结构损伤期通脉道护枢机、多器官受累期和脏腑救逆乱。

Abstract

Based on the theory of

and blood in traditional Chinese medicine， this paper innovatively put forward and constructed the three-dimensional dynamic disease mechanism model of "

transportating in the vessels， blood flowing in the vessels， and the vessels as the pivot"， which points out that the vessels are the key pivot for the transportation of

and blood， when vessels are unobstructed， they maintain normal physiological functions； when vessels lose their regulatory role， diseases occur. This model also explains the law of dynamic pathogenesis evolution of coronary atherosclerotic heart disease （CAD）， in which CAD is divided into three stages. At dysfunction stage， riggers such as emotional disturbance lead to abnormal

movement， slowing down the distribution of

and blood， and inducing early symptoms of CAD， which are mainly manifested as functional disorders. At structural damage stage， the pivot regulatory function of vessels is lost， resulting in stagnation of

and blood， and accumulation of phlegm and blood stasis， which further causes structural damage to vessels， leading to a more complex condition. At multi-organ involvement stage， vessels fail to act as the pivot， causing disordered flow of

and blood and involvement of multiple

zang

organs， eventually leading to systemic failure with a poor prognosis. In terms of treatment strategies， based on the characteristics of different stages， a three-in-one therapeutic principle of "regulating

， smoothing vessels， and activating blood" is proposed， so as to regulate

and blood to restore the pivot function of vessels during dysfunctional stage， to unblock vessels and protect their pivot function during structural damage stage， and to harmonize

zang

organs and correct the disordered

and blood during multi-organ involvement stage.

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references

SHAREBIANI H ， MOKARAM M ， MIRGHANI M ， et al . The effects of antioxidant supplementation on the pathologic mechanisms of metabolic syndrome and cardiovascular disease development ［J］. Nutrients ， 2024 ， 16 （ 11 ）： 1614 .

XU S ， ILYAS I ， LITTLE PJ ， et al . Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond： from mechanism to pharmacotherapies ［J］. Pharmacol Rev ， 2021 ， 73 （ 3 ）： 924 - 967 .

刘应科，孙光荣 . 中医临证的四大核心理念之整体观［J］. 湖南中医药大学学报， 2016 ， 36 （ 5 ）： 1 - 5 .

杨梅，鲁法庭，王青，等 . 中医恒动观念的形成及其在中医诊断中的应用［J］. 云南中医学院学报， 2011 ， 34 （ 5 ）： 1 - 3 .

马龙，王至婉 . 中医核心病机研究方法及现存问题概述［J］. 时珍国医国药， 2024 ， 35 （ 3 ）： 683 - 685 .

罗桂青，李磊 . 试论“心主血脉” ［J］. 河南中医， 2011 ， 31 （ 5 ）： 452 - 454 .

岳小强，杨学 . 三阴三阳的位序与《伤寒论》六经“开、阖、枢 ”［J］. 中西医结合学报， 2008 ， 6 （ 12 ）： 1294 - 1296 .

张铜五，陈向心，陆毅，等 . 《黄帝内经》“血脉”整体观防治动脉粥样硬化性心血管疾病的理论发挥［J］. 实用中医内科杂志， 2024 ， 38 （ 6 ）： 1 - 4 .

刘建勋，陈进成，郭浩，等 . 气血交互于脉的理论基础与实践［J］. 中医杂志， 2020 ， 61 （ 2 ）： 98 - 102 .

李成晨，黄益清，李小梅，等 . 血脉、经络源流演绎与体用辨析［J］. 中医药导报， 2023 ， 29 （ 9 ）： 125 - 128 .

彭涵，辛高杰，曹策，等 . 基于“气血交互于脉”理论探讨益气活血中药防治心肌缺血再灌注损伤的作用机制［J］. 中国实验方剂学杂志， 2024 ， 30 （ 23 ）： 27 - 34 .

向阳，杨海燕，赵春生，等 . 基于线粒体心肌能量代谢探讨从“气”治疗慢性心力衰竭［J］. 中国民族民间医药， 2021 ， 30 （ 2 ）： 5 - 8 .

向怡，许滔，郭磊磊，等 . 《内经》“气脉常通”之气脉和治在心肌能量代谢异常干预中的运用探析［J］. 贵州中医药大学学报， 2023 ， 45 （ 5 ）： 23 - 28 .

褚雨霆 . 基于血管因子生物学特性探讨从脾论治免疫性血小板减少症疗效机制［D］. 北京：北京中医药大学， 2017 .

陈可冀，李连达，翁维良 . 血瘀证与活血化瘀研究［J］. 中西医结合心脑血管病杂志， 2005 ， 3 （ 1 ）： 1 - 2 .

黄克，左可可，顾宁 . 基于血管内皮功能探讨冠状动脉微循环障碍“虚气留滞”病机的科学内涵［J］. 辽宁中医药大学学报， 2025 ， 27 （ 7 ）： 44 - 49 .

王阶，陈光 . 冠心病稳定型心绞痛中医诊疗专家共识［J］. 中医杂志， 2018 ， 59 （ 5 ）： 447 - 450 .

袁舒，魏巧 . 冠心丹参滴丸治疗冠心病心绞痛的效果观察［J］. 慢性病学杂志， 2020 ， 21 （ 6 ）： 855 - 856 .

陈媛，林尤斌，吴清柳，等 . 冠心丹参滴丸对老年冠状动脉粥样硬化性心脏病不稳定型心绞痛患者血小板活化功能及血清MMP-9、sICAM-1及tPAI-1水平的影响［J］. 世界临床药物， 2020 ， 41 （ 2 ）： 111 - 117 .

孙夕童，范新彪，耿小飞，等 . 脉中积理论指导下的动脉粥样硬化时间序贯辨治思路：以冠心病为例［J］. 中医杂志， 2025 ， 66 （ 18 ）： 1891 - 1894 .

李然，谢朋呈，辛高杰，等 . 双参芎连颗粒对动脉粥样硬化大鼠腹主动脉斑块的影响［J］. 中国中医药信息杂志， 2022 ， 29 （ 9 ）： 101 - 105 .

谷文超，张梁坤，王芙蓉，等 . 生脉散历史沿革及研究现状分析［J］. 世界中医药， 2025 ， 20 （ 15 ）： 2776 - 2782 .

辛高杰，陈原原，刘子馨，等 . 双参宁心胶囊调控线粒体分裂、融合减轻大鼠心肌缺血再灌注损伤［J］. 中国实验方剂学杂志， 2024 ， 30 （ 7 ）： 87 - 94 .

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Discussion on the Dynamic Pathogenesis of Coronary Heart Disease from the Perspective of "Qi Transporting in the Vessels，Blood Flowing in the Vessels，and the Vessels are the Pivotal"

DOI：10.13288/j.11-2166/r.2025.24.015

摘要

Abstract

关键词

Keywords

references