<italic style="font-style: italic">Ganye Pingchan Decoction</italic> （感夜平颤方） for Patients with Early-Moderate Parkinson's Disease Complicated with Rapid Eye Movement Sleep Behavior Disorder on Sleep and Blood Pressure Circadian Rhythm Disorders： A Randomized Controlled Trial

WU You; YE Qing; YUAN Canxing; XU Limin; YANG Baican; YANG Yiwen

doi:10.13288/j.11-2166/r.2026.03.010

您当前的位置：

首页 >

文章列表页 >

Ganye Pingchan Decoction （感夜平颤方） for Patients with Early-Moderate Parkinson's Disease Complicated with Rapid Eye Movement Sleep Behavior Disorder on Sleep and Blood Pressure Circadian Rhythm Disorders： A Randomized Controlled Trial

更新时间：2026-02-04

- Ganye Pingchan Decoction （感夜平颤方） for Patients with Early-Moderate Parkinson's Disease Complicated with Rapid Eye Movement Sleep Behavior Disorder on Sleep and Blood Pressure Circadian Rhythm Disorders： A Randomized Controlled Trial
- Journal of Traditional Chinese Medicine Vol. 67, Issue 3, Pages: 283-290(2026)
- 作者机构：
  
  1.上海中医药大学附属龙华医院，上海市徐汇区宛平南路725号，200032
  2.上海中医药大学中药学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2026.03.010
  CLC：
- Received：10 September 2025，
  
  Revised：2025-11-15，
  
  Published：02 February 2026
- 稿件说明：
移动端阅览
吴攸,叶青,袁灿兴等.感夜平颤方治疗早中期帕金森病伴快速眼动睡眠行为障碍患者睡眠及血压昼夜节律紊乱的临床研究[J].中医杂志,2026,67(03):283-290.

WU You,YE Qing,YUAN Canxing,et al.Ganye Pingchan Decoction （感夜平颤方） for Patients with Early-Moderate Parkinson's Disease Complicated with Rapid Eye Movement Sleep Behavior Disorder on Sleep and Blood Pressure Circadian Rhythm Disorders： A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(03):283-290.
吴攸,叶青,袁灿兴等.感夜平颤方治疗早中期帕金森病伴快速眼动睡眠行为障碍患者睡眠及血压昼夜节律紊乱的临床研究[J].中医杂志,2026,67(03):283-290. DOI： 10.13288/j.11-2166/r.2026.03.010.

WU You,YE Qing,YUAN Canxing,et al.Ganye Pingchan Decoction （感夜平颤方） for Patients with Early-Moderate Parkinson's Disease Complicated with Rapid Eye Movement Sleep Behavior Disorder on Sleep and Blood Pressure Circadian Rhythm Disorders： A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(03):283-290. DOI： 10.13288/j.11-2166/r.2026.03.010.

摘要

目的

探讨感夜平颤方治疗早中期帕金森病（PD）伴快速眼动睡眠行为障碍（RBD）患者睡眠及血压昼夜节律紊乱的临床疗效。

方法

将80例早中期PD伴RBD患者随机分为治疗组与对照组各40例。对照组采用西药常规治疗联合感夜平颤方安慰剂，治疗组采用西药常规治疗联合感夜平颤方。两组疗程均为12周。分别于治疗前后检测两组患者帕金森病综合评定量表（UPDRS）、香港中文大学快速眼动睡眠期行为障碍量表（RBDQ-HK）、帕金森病睡眠量表（PDSS）、多导睡眠图（PSG）、唾液褪黑素分泌节律及24小时动态血压参数变化情况。

结果

与本组治疗前相比，治疗后两组患者RBDQ-HK和UPDRS评分均降低，治疗组PDSS评分升高，对照组PDSS评分降低；治疗组患者的睡眠效率提高，微觉醒次数和微觉醒指数降低；两组患者的N3期占比均提高，快速动眼睡眠（REM）活动度、REM强度和REM密度均降低；两组患者褪黑素分泌中位数均提高，治疗组褪黑素分泌振幅提高；治疗组夜间收缩压下降率（△n-SBP）提高，且非杓型血压节律患者比例增加（

＜0.05）。治疗后治疗组UPDRS、RBDQ-HK评分、微觉醒次数、微觉醒指数均低于对照组，日间平均收缩压（d-SBP）、△n-SBP高于对照组（

＜0.05）。

结论

感夜平颤方能够调节早中期PD伴RBD患者睡眠及血压昼夜节律，提高睡眠效率、减少睡眠碎片化，调节褪黑素昼夜分泌节律，提高夜间收缩压下降率，且安全性良好。

Abstract

Objective

To investigate the clinical effectiveness of

Ganye Pingchan Decoction

（感夜平颤方） for patients with early-moderate Parkinson's disease （PD） complicated with rapid eye movement sleep behavior disorder （RBD） on sleep and blood pressure circadian rhythm disorders.

Methods

A total of 80 patients with early-moderate PD patients with RBD were randomly assigned to either a treatment group or a control group， with 40 patients in each group. The control group received conventional western medicine plus placebo of

Ganye Pingchan Decoction

， while the treatment group received conventional western medicine combined with

Ganye Pingchan Decoction

. The course of treatment for both groups was 12 weeks. Changes in the Unified Parkinson's Disease Rating Scale （UPDRS）， Hong Kong Rapid Eye Movement Sleep Behavior Disorder Questionnaire （RBDQ-HK）， Parkinson's Disease Sleep Scale （PDSS）， polysomnography （PSG）， salivary melatonin （SM） secretion rhythms， and 24-hour ambulatory blood pressure before and after treatment were measured in both groups.

Results

Compared with the baseline data within group， the scores of RBDQ-HK and UPDRS decreased in both groups after treatment； the PDSS score increased in the treatment group but decreased in the control group； in the treatment group， sleep efficiency was improved， and the number and index of microarousals reduced； the proportion of N3 sleep stage increased， while rapid eye movement （REM） activity， REM intensity and REM density decreased in both groups； the median SM secretion level increased in both groups， and the amplitude of SM secretion elevated in the treatment group； in the treatment group， the nocturnal systolic blood pressure decline rate （n-SBP） increased， and the proportion of patients with non-dipper blood pressure rhythm raised （

＜0.05）. After treatment， the scores of UPDRS and RBDQ-HK， as well as the n

umber and index of microarousals in the treatment group were significantly lower than those in the control group； the daytime mean systolic blood pressure （d-SBP） and △n-SBP in the treatment group were higher than those in the control group （

＜0.05）.

Conclusion

Ganye Pingchan Decoction

can effectively regulate sleep and blood pressure circadian rhythms in patients with early-moderate PD complicated with RBD. It can improve sleep efficiency， reduce sleep fragmentation， regulate the circadian rhythm of SM secretion， increase the nocturnal systolic blood pressure decline rate， with good safety.

关键词

Keywords

references

NASSAN M ， VIDENOVIC A . Circadian rhythms in neurodegenerative disorders ［J］. Nat Rev Neurol ， 2022 ， 18 （ 1 ）： 7 - 24 .

SHEN Y ， LV QK ， XIE WY ， et al . Circadian disruption and sleep disorders in neurodegeneration ［J］. Transl Neurodegener ， 2023 ， 12 （ 1 ）： 8 .

TANNER CM ， OSTREM JL . Parkinson's Disease ［J］. N Engl J Med ， 2024 ， 391 （ 5 ）： 442 - 452 .

SMILOWSKA K ， VAN WAMELEN DJ ， BLOEM BR . The multimodal effect of circadian interventions in Parkinson's disease： a narrative review ［J］. Parkinsonism Relat Disord ， 2023 ， 110 ： 105309.1 - 12 . doi： 10.1016/j.parkreldis.2023. 105309 http://dx.doi.org/10.1016/j.parkreldis.2023.105309 .

LIU Y ， NIU L ， LIU X ， et al . Recent progress in non-motor features of Parkinson's disease with a focus on circadian rhythm dysregulation ［J］. Neurosci Bull ， 2021 ， 37 （ 7 ）： 1010 - 1024 .

吴攸，袁灿兴 . 帕金森病临床异质性的中西医研究进展［J］. 上海中医药杂志， 2021 ， 55 （ 8 ）： 104 - 108 .

TURKISTANI A ， AL-KURAISHY HM ， AL-GAREEB AI ， et al . Blunted melatonin circadian rhythm in Parkinson's disease： express bewilderment ［J］. Neurotox Res ， 2024 ， 42 （ 5 ）： 38 .

LI T ， CHENG C ， JIA C ， et al . Peripheral clock system abnormalities in patients with Parkinson's disease ［J］. Front Aging Neurosci ， 2021 ， 13 ： 736026 . doi： 10.3389/fnagi.2021.736026 http://dx.doi.org/10.3389/fnagi.2021.736026 .

MUSIEK ES ， HOLTZMAN DM . Mechanisms linking circadian clocks， sleep， and neurodegeneration ［J ］. Science ， 2016 ， 354 （ 6315 ）： 1004 - 1008 .

周洁，叶青，袁灿兴，等 . 滋补肝肾、通络解毒法治疗帕金森病［J］. 中医杂志， 2018 ， 59 （ 14 ）： 1241 - 1243，1251 .

GU SC ， SHI R ， GAOAG C ， et al . Traditional Chinese medicine Pingchan granule for motor symptoms and functions in Parkinson's disease： a multicenter， randomized， double-blind， placebo-controlled study ［J］. Phytomedicine ， 2023 ， 108 ： 154497 . doi： 10.1016/j.phymed.2022. 154497 http://dx.doi.org/10.1016/j.phymed.2022.154497 .

吴攸 . 早中期帕金森病的临床异质性及平颤方治疗不同运动亚型的疗效研究［D］. 上海：上海中医药大学， 2021 .

中华医学会神经病学分会帕金森病及运动障碍学组，中国医师协会神经内科医师分会帕金森病及运动障碍专业委员会 . 中国帕金森病的诊断标准（2016版）［J］. 中华神经科杂志， 2016 ， 49 （ 4 ）： 268 - 271 .

HOEHN MM ， YAHR MD . Parkinsonism： onset， progression and mortality ［J］. Neurology ， 1967 ， 17 （ 5 ）： 427 - 442 .

中华医学会神经病学分会睡眠障碍学组，中国医师协会睡眠医学专委会神经学组 . 快速眼动睡眠期行为障碍诊断和治疗指南（2025版）［J］. 中华医学杂志， 2025 ， 105 （ 37 ）： 3266 - 3283 .

O'HAGAN A ， STEVENS JW ， CAMPBELL MJ . Assu-rance in clinical trial design ［J］. Pharm Stat ， 2010 ， 4 （ 3 ）： 187 - 201 .

CHAUDHURI KR ， PAL S ， DIMARCO A ， et al . The Parkinson's disease sleep scale： a new instrument for assessing sleep and nocturnal disability in Parkinson's disease ［J］. J Neurol Neurosurg Psychiatry ， 2002 ， 73 ： 629 - 635 . doi： 10.1136/jnnp.73.6.629 http://dx.doi.org/10.1136/jnnp.73.6.629 .

MARTÍNEZ-MARTÍN P ， GIL-NAGEL A ， GRACIA LM ， et al . Unified Parkinson's disease rating scale characte-ristics and structure. the cooperative multicentric group ［J］. Mov Disord ， 1994 ， 9 ： 76 - 83 . doi： 10.1002/mds. 870090112 http://dx.doi.org/10.1002/mds.870090112 .

黎锦标，王艳丽，赖洪萍，等 . 多导睡眠监测在帕金森病伴睡眠障碍中应用的研究进展［J］. 中国医学创新， 2025 ， 22 （ 24 ）： 172 - 178 .

中华医学会，中华医学会杂志社，高血压联盟（中国，等 . 中国动态血压监测基层应用指南（2024年）［J］. 中华全科医师杂志， 2024 ， 23 （ 12 ）： 1242 - 1255 .

STEFANI A ， ANTELMI E ， ARNALDI D ， et al . From mechanisms to future therapy： a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease ［J］. Mol Neurodegener ， 2025 ， 20 （ 1 ）： 19 .

CZEISLER CA ， WEITZMAN E ， MOORE-EDE MC ， et al . Human sleep： its duration and organization depend on its circadian phase ［J］. Science ， 1980 ， 210 （ 4475 ）： 1264 - 1267 .

CARDINALI DP ， GARAY A . Melatonin as a chronobiotic/cytoprotective agent in rem sleep behavior disorder ［J］. Brain Sci ， 2023 ， 13 （ 5 ）： 1 - 19 .

OHAYON MM ， SCHENCK CH . Violent behavior during sleep： prevalence， comorbidity and consequences ［J］. Sleep Med ， 2010 ， 11 （ 9 ）： 941 - 946 .

HÖGL B ， STEFANI A ， VIDENOVIC A . Idiopathic REM sleep behaviour disorder and neurodegeneration：an update ［J］. Nat Rev Neurol ， 2018 ， 14 （ 1 ）： 40 - 55 .

OHNUKI T ， UEDA M ， YAMAMURA S . Molecular mechanism of the control of nyctinastic leaf-movement in Lespedeza cuneata G.Don ［J］. Tetrahedron ， 1998 ， 54 （ 40 ）： 12173 - 12184 .

YANG Y ， WU Y ， XU P ， et al . Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters ［J］. Ann Transl Med ， 2021 ， 9 （ 20 ）： 1524 .

肖仁清，万赢，刘振国 . 帕金森病患者血压昼夜节律紊乱的研究进展［J］. 中华神经科杂志， 2021 ， 54 （ 12 ）： 1307 - 1311 .

WILSON H ， DERVENOULAS G ， PAGANO G ， et al . Serotonergic pathology and disease burden in the premotor and motor phase of A53T α-synuclein parkinsonism： a cross-sectional study ［J］. Lancet Neurol ， 2019 ， 18 （ 8 ）： 748 - 759 .

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Professor ZHOU Shaohua's Experience in Staged Treatment of Parkinson's Disease Based on the "Disease-Symptom-Syndrome Integration" Approach

Effects of Bushen Zhichan Formula （补肾止颤方） on Ferroptosis of Dopaminergic Neurons and Nrf2-Regulated SLC7A11/GSH/GPX4 Signaling Pathway in Parkinson's Disease Model Rats

Effect of Bushen Huoxue Granule （补肾活血颗粒） on Dopamine Homeostasis and ERK/CREB/VMAT2 Signaling Pathways in the Striatum in Parkinson's Disease Model Mice

Efficacy and Safety of Acupuncture Combined with Levodopa in the Treatment of Parkinson's Disease： A Randomized Controlled Trial

Effect of Bushen Huoxue Granules （补肾活血颗粒） on the Nrf2/NLRP3 Inflammasome Axis in the Brain Substantia Nigra of Parkinson's Disease Model Mice

Related Author

XU Dinglin

WANG Jiayi

GE Liwei

GUO Chunli

周绍华

HU Yuying

CHEN Weiying

SONG Xi

Related Institution

Graduate School，Beijing University of Chinese Medicine

Xiyuan Hospital，China Academy of Chinese Medical Sciences

Guangxi University of Chinese Medicine

The First Affiliated Hospital of Guangxi University of Chinese Medicine

Chinese People's Liberation Army Medical School

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

Ganye Pingchan Decoction （感夜平颤方） for Patients with Early-Moderate Parkinson's Disease Complicated with Rapid Eye Movement Sleep Behavior Disorder on Sleep and Blood Pressure Circadian Rhythm Disorders： A Randomized Controlled Trial

DOI：10.13288/j.11-2166/r.2026.03.010

摘要

Abstract

关键词

Keywords

references