Mechanisms of Hepatotoxicity Induced by Toxic Chinese Herbal Medicinals and Compatibility-Based Detoxification Strategies from the Perspective of the "Liver Aversion to Acute Irritation" Theory
|更新时间:2026-05-19
|
Mechanisms of Hepatotoxicity Induced by Toxic Chinese Herbal Medicinals and Compatibility-Based Detoxification Strategies from the Perspective of the "Liver Aversion to Acute Irritation" Theory
Journal of Traditional Chinese MedicineVol. 67, Issue 5, Pages: 487-491(2026)
LI Xiang,GUO Liuyang,YU Zhichao,et al.Mechanisms of Hepatotoxicity Induced by Toxic Chinese Herbal Medicinals and Compatibility-Based Detoxification Strategies from the Perspective of the "Liver Aversion to Acute Irritation" Theory[J].Journal of Traditional Chinese Medicine,2026,67(05):487-491.
LI Xiang,GUO Liuyang,YU Zhichao,et al.Mechanisms of Hepatotoxicity Induced by Toxic Chinese Herbal Medicinals and Compatibility-Based Detoxification Strategies from the Perspective of the "Liver Aversion to Acute Irritation" Theory[J].Journal of Traditional Chinese Medicine,2026,67(05):487-491.DOI: 10.13288/j.11-2166/r.2026.05.005.
Mechanisms of Hepatotoxicity Induced by Toxic Chinese Herbal Medicinals and Compatibility-Based Detoxification Strategies from the Perspective of the "Liver Aversion to Acute Irritation" Theory
This study establishes an integrated research paradigm based on traditional Chinese medicine (TCM) theory, guided by pathological characteristics, centered on formula compatibility principles, and supported by multidisciplinary technologies, to systematically analyze the mechanisms of hepatotoxicity induced by toxic Chinese herbal medicinals and strategies for reducing toxicity through compatibility. The findings revealed that the pathomechanism aligns closely with the "liver aversion to acute irritation" theory from
Inner Canon of Yellow Emperor
(《黄帝内经》). The core pathology involves an imbalance between liver's form and function, which is characterized by malnourishment of liver form due to
yin
-blood depletion and dysfunction in ascending-dispersing and free-flowing activities, and closely linked to modern pathological mechanisms such as microcirculatory disturbances, oxidative stress, inflammatory response, metabolic disorder and gut
-liver axis dysregulation. Based on this, a multi-layered compatibility strategy for toxicity reduction is put forward, which involves using sweet medicinals to alleviate urgency, balancing the liver form and its function, and pre-regulating other organs. This provides a theoretical basis for the safe application of toxic Chinese herbal medicinals.
ZHAO C , LI E , WANG Z , et al . Nux vomica exposure triggered liver injury and metabolic disturbance in zebra-fish larvae [J]. Zebrafish , 2018 , 15 ( 6 ): 610 - 628 .
BHOGAL RH , CURBISHLEY SM , WESTON CJ , et al . Reactive oxygen species mediate human hepatocyte injury during hypoxia/reoxygenation [J]. Liver Transpl , 2010 , 16 ( 11 ): 1303 - 1313 .
DE AGUIAR VALLIM TQ , TARLING EJ , AHN H , et al . MAFG Is a transcriptional repressor of bile acid synthesis and metabolism [J]. Cell Metab , 2015 , 21 ( 2 ): 298 - 311 .
TRIPATHI A , DEBELIUS J , BRENNER DA , et al . The gut-liver axis and the intersection with the microbiome [J]. Nat Rev Gastroenterol Hepatol , 2018 , 15 ( 7 ): 397 - 411 .
Analysis of the Nature,Flavor and Combination Characteristics of the Two-herb Compound Formulas inTreatise on Cold Damage and Miscellaneous Diseases (《伤寒杂病论》)
Effect of Erzhi Pill (二至丸) of Different Dosing Time on the Expression of Biological Clock-related Factors Bmal1 and Cry1 in the Liver Tissue of Aging Liver Injury Model Mice
Retrospective Analysis of Correlation between Traditional Chinese Medicine Treatment and Liver Injury in Coronavirus Disease 2019 (COVID-19)
Effect of Yiqi Huatan Quyu Recipe (益气化痰祛瘀方) on Liver and Intestinal Microorganism in Chronic Intermittent Hypoxia Model Rats
Effects of American Ginseng Capsules on the Liver Ultrastructure and the Oxidative Stress of Rats after Exposure to Electromagnetic Radiation
Related Author
SHI Dazhuo
JIANG Zhonghui
GAO Zhuye
DU Jianpeng
DUAN Wenhui
BAI Ruina
SHANG Qinghua
ZHAO Yihan
Related Institution
Institute of Cardiovascular Diseases,Xiyuan Hospital,China Academy of Chinese Medical Sciences
School of Basic Medicine, Henan University of Science and Technology
Beijing Ditan Hospital, Capital Medical University
Clinical Skills Teaching Center of Fujian University of Traditional Chinese Medicine
College of Integrated Traditional Chinese and Western Medicine,Fujian University of Traditional Chinese Medicine