Effects of Moxibustion on Ginger Combined with High Tryptophan Diet on Clinical Efficacy and Immune Function in Chronic Fatigue Syndrome Patients with Spleen-Kidney <italic style="font-style: italic">Yang</italic> Deficiency：A Randomized Controlled Trial

LI Huan; LIU Baoliang; SHEN Dongdong; HOU Jianghong; LIU Kunpeng

doi:10.13288/j.11-2166/r.2026.08.010

您当前的位置：

首页 >

文章列表页 >

Effects of Moxibustion on Ginger Combined with High Tryptophan Diet on Clinical Efficacy and Immune Function in Chronic Fatigue Syndrome Patients with Spleen-Kidney Yang Deficiency：A Randomized Controlled Trial

更新时间：2026-04-16

- Effects of Moxibustion on Ginger Combined with High Tryptophan Diet on Clinical Efficacy and Immune Function in Chronic Fatigue Syndrome Patients with Spleen-Kidney Yang Deficiency：A Randomized Controlled Trial
- Journal of Traditional Chinese Medicine Vol. 67, Issue 8, Pages: 862-867(2026)
- 作者机构：
  
  河南省中医院/河南中医药大学第二附属医院，河南省郑州市金水区东风路6号，450046
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2026.08.010
  CLC：
- Received：19 May 2025，
  
  Revised：2026-02-15，
  
  Accepted：08 January 2026，
  
  Published：17 April 2026
- 稿件说明：
移动端阅览
李欢,刘宝良,申冬冬等.隔姜灸联合高色氨酸饮食对脾肾阳虚型慢性疲劳综合征患者疗效与免疫功能影响的随机对照试验[J].中医杂志,2026,67(08):862-867.

LI Huan,LIU Baoliang,SHEN Dongdong,et al.Effects of Moxibustion on Ginger Combined with High Tryptophan Diet on Clinical Efficacy and Immune Function in Chronic Fatigue Syndrome Patients with Spleen-Kidney Yang Deficiency：A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(08):862-867.
李欢,刘宝良,申冬冬等.隔姜灸联合高色氨酸饮食对脾肾阳虚型慢性疲劳综合征患者疗效与免疫功能影响的随机对照试验[J].中医杂志,2026,67(08):862-867. DOI： 10.13288/j.11-2166/r.2026.08.010.

LI Huan,LIU Baoliang,SHEN Dongdong,et al.Effects of Moxibustion on Ginger Combined with High Tryptophan Diet on Clinical Efficacy and Immune Function in Chronic Fatigue Syndrome Patients with Spleen-Kidney Yang Deficiency：A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(08):862-867. DOI： 10.13288/j.11-2166/r.2026.08.010.

摘要

目的

探讨隔姜灸联合高色氨酸饮食对脾肾阳虚型慢性疲劳综合征（CFS）患者的临床疗效及对免疫功能的影响。

方法

将90例脾肾阳虚型CFS患者随机分为隔姜灸组、对照组和假灸组，每组30例。各组均给予高色氨酸饮食干预，同时隔姜灸组采用隔姜灸大椎、膈俞（双侧）、脾俞（双侧）、肾俞（双侧）、中脘、天枢（双侧）、关元，对照组于上述各穴位向外侧旁开2 cm处施灸，操作同隔姜灸组；假灸组仅将加热姜片放置于穴位上，不放置艾柱。各组均每日治疗1次，每穴灸3~5壮，10次为1个疗程，疗程之间间隔3天，共治疗3个疗程。比较各组治疗前后疲劳评定量表（FAI）评分、外周血T淋巴细胞亚群指标（CD3⁺、CD4⁺、CD8⁺百分比及CD4⁺/CD8⁺比值）和体液免疫指标［免疫球蛋白G（IgG）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）］的变化。治疗结束评价各组临床疗效与安全性指标。

结果

隔姜灸组临床总有效率为93.3%（28/30），对照组为83.3%（25/30），假灸组为50.0%（15/30），隔姜灸组和对照组均优于假灸组（

＜0.05）。治疗后各组FAI评分均较本组治疗前下降（

＜0.05），T细胞免疫及体液免疫指标均有不同程度改善。

治疗后，隔姜灸组FAI评分低于对照组和假灸组（

＜0.05）；隔姜灸组CD3⁺、CD4⁺百分比，CD4⁺/CD8⁺比值，IgG、IgA、IgM水平均显著高于对照组与假灸组，CD8⁺百分比显著低于对照组与假灸组（

＜0.05）；对照组FAI评分低于假灸组（

＜0.05）。各组均未出现严重不良反应。

结论

隔姜灸联合高色氨酸饮食可显著改善脾肾阳虚型CFS患者的疲劳症状，其机制涉及增强细胞免疫及体液免疫功能。

Abstract

Objective

To evaluate the clinical efficacy and immunomodulatory effects of moxibustion on ginger combined with a high tryptophan diet in chronic fatigue syndrome （CFS） patients with spleen-kidney

yang

deficiency syndrome.

Methods

Ninety CFS patients with spleen-kidney

yang

deficiency syndrome were randomly assigned to moxibustion on ginger group， control group， and sham moxibustion group， with 30 cases in each group. All groups were given a high-tryptophan diet intervention. The moxibustion group additionally received ginger-separated moxibustion at Dazhui （GV 14）， bilateral Geshu （BL 17）， bilateral Pishu （BL 20）， bilateral Shenshu （BL 23）， Zhongwan （CV 12）， bilateral Tianshu （ST 25）， and Guanyuan （CV 4）， while the control group received the same procedures as the moxibustion group but at non-specific points （2 cm lateral to the above acupoints）， and the sham moxibustion group received only heated ginger slices at acupoints without moxa. Treatments were administered once daily， with 3~5 moxa cones per acupoint per session. Each course consisted of 10 sessions with a 3-day interval between courses， for a total of 3 courses. The changes in fatigue assessment instrument （FAI） scores， peripheral blood T cell subsets including CD3⁺， CD4⁺， CD8⁺ percentages and CD4⁺/CD8⁺ ratio， and humoral immune indicators including immunoglobulin G （IgG）， immunoglobulin A （IgA）， and immunoglobulin M （IgM） were compared before and after treatment among the three groups. Clinical efficacy and safety indicators were evaluated at the end of the treatment.

Results

e total effective rate was 93.3% （28/30） in the moxibustion on ginger group， 83.3% （25/30） in the control group， and 50.0% （15/30） in the sham moxibustion group， and the moxibustion on ginger and the control group outperforming the sham moxibustion group （

＜0.05）. After treatment， the FAI scores in all groups significantly decreased （

＜0.05）， and T-cell subsets and humoral immune indicators showed varying degrees of improvement. After treatment， the moxibustion group showed the most significant reduction in FAI scores （

＜0.05）， the greatest increases in CD3⁺， CD4⁺ T cell percentages， CD4⁺/CD8⁺ ratio， and levels of IgG， IgA， IgM， and the lowest CD8⁺ percentage compared to the control group and the sham moxibustion group （

＜0.05）. The control group had lower FAI scores than the sham moxibustion group （

＜0.05）. No serious adverse events were observed in any group.

Conclusion

Moxibustion on ginger combined with a high tryptophan diet can significantly improve fatigue symptoms in CFS patients with spleen-kidney

yang

deficiency syndrome. The mechanism involves enhancing both cellular and humoral immune functions.

关键词

Keywords

references

Oslo Chronic Fatigue Consortium ， ALME T N ， ANDREASSON A ， et al . Chronic fatigue syndromes： real illnesses that people can recover from ［J］. Scand J Prim Health Care ， 2023 ， 41 （ 4 ）： 372 - 376 .

潘泗红，张振贤，黄瑶，等 . 慢性疲劳综合征流行病学、病因及病机的研究进展［J］. 临床医学研究与实践， 2024 ， 9 （ 21 ）： 195 - 198 .

王丹，王娜娜 . 慢性疲劳综合征的中西医治疗研究进展探析［J］. 中医临床研究， 2024 ， 16 （ 21 ）： 134 - 138 .

康明祥 . 慢性疲劳综合征中医症候流行病学调查和证型研究［D］. 泸州：泸州医学院， 2009 .

BINKS H ， E VINCENT G ， GUPTA C ， et al . Effects of diet on sleep： a narrative review ［J］. Nutrients ， 2020 ， 12 （ 4 ）： 936 .

FUKUDA K ， STRAUS S E ， HICKIE I ， et al . The chronic fatigue syndrome： a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group ［J］. Ann Intern Med ， 1994 ， 121 （ 12 ）： 953 - 959 .

郑筱萸．中药新药临床研究指导原则（试行）［M］. 北京：中国医药科技出版社， 2002 ： 119 ．

SCHWARTZ J E ， JANDORF L ， KRUPP L B . The measurement of fatigue： a new instrument ［J］. J Psychosom Res ， 1993 ， 37 （ 7 ）： 753 - 762 .

杨月欣 . 中国食物成分表：第1册［M］. 6版 . 北京：北京大学医学出版社， 2018 ： 121 - 122 .

RAIJ T ， RAIJ K . Association between fatigue， peripheral serotonin， and L-carnitine in hypothyroidism and in chronic fatigue syndrome ［J］. Front Endocrinol （Lausanne）， 2024 ， 151358404 . doi： 10.3389/fendo.2024.1358404 http://dx.doi.org/10.3389/fendo.2024.1358404 .

JENKINS T A ， NGUYEN J C ， POLGLAZE K E ， et al . Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis ［J］. Nutrients ， 2016 ， 8 （ 1 ）： 56 .

BELTRA J C ， MANNE S ， ABDEL-HAKEEM M S ， et al . Developmental relationships of four exhausted CD8 + T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms ［J］. Immunity ， 2020 ， 52 （ 5 ）： 825 - 841 .

PABST O ， SLACK E . IgA and the intestinal microbiota： the importance of being specific ［J］. Mucosal Immunol ， 2020 ， 13 （ 1 ）： 12 - 21 .

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with Qi Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial

Effect of Qingfei Shenshi Decoction （清肺渗湿汤） Combined with Western Medicine on Clinical Effectiveness and Immune Function for Patients with Bronchial Asthma of Heat Wheezing Syndrome

Effects of Yiqi Fuyuan Paste （益气复元膏方） on Immune Function in Sub-Health People with Qi Deficiency Constitutions and Analysis of the Characteristics of Their Tongue and Pulse Manifestations

Effect of Modified Lurong Sancao Decoction （鹿蓉三草汤） on Quality of Life and Immune Function in Differentiated Thyroid Cancer Patients after Surgery：A Randomized Controlled Trial

Treating Post-viral Chronic Fatigue Syndrome from the Perspective of Deficiency of Pectoral and Defensive Qi

Related Author

ZHAN Wenhao

DING Qian

DONG Zhiwei

LI Ting

FU Shumei

TIAN Ning

SUN Ying

HU Haibo

Related Institution

Jinan Vocational College of Nurisng，Shandong Pronvince

Guangdong Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Guangzhou University of Chinese Medicine

First Clinical Medical College，Shandong University of Traditional Chinese Medicine

Qingdao Traditional Chinese Medicine Hospital （Qingdao Hiser Hospital）

First Affiliated Hospital of Zhejiang Chinese Medical University / Zhejiang Provincial Hospital of Traditional Chinese Medicine

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

Effects of Moxibustion on Ginger Combined with High Tryptophan Diet on Clinical Efficacy and Immune Function in Chronic Fatigue Syndrome Patients with Spleen-Kidney Yang Deficiency：A Randomized Controlled Trial

DOI：10.13288/j.11-2166/r.2026.08.010

摘要

Abstract

关键词

Keywords

references