QI Xiaorong,WEI Naxin,LI Min.Treatment of Acute Respiratory Distress Syndrome from the Perspective of Qi Deficiency and Blood Stasis[J].Journal of Traditional Chinese Medicine,2026,67(08):908-911.
QI Xiaorong,WEI Naxin,LI Min.Treatment of Acute Respiratory Distress Syndrome from the Perspective of Qi Deficiency and Blood Stasis[J].Journal of Traditional Chinese Medicine,2026,67(08):908-911.DOI: 10.13288/j.11-2166/r.2026.08.017.
Treatment of Acute Respiratory Distress Syndrome from the Perspective of Qi Deficiency and Blood Stasis
Based on the analysis of the core pathological changes of acute respiratory distress syndrome (ARDS) in modern medicine, and combining traditional Chinese medicine (TCM) understanding of the pathogenesis and clinical practice for ARDS, it is believed that
qi
deficiency and blood stasis is the main pathogenesis in the middle and late stages of ARDS. It is proposed to employ the therapeutic principle of "boosting
qi
and invigorating blood" as its primary treatment approach. The method of boosting
qi
can reinforce healthy
qi
and consolidate the root, regulate the inflammatory response and improve the impaired tissue repair ability, while the method of invigorating blood is used to dissolve stasis, unblock collaterals, and correct thrombus formation and hemodynamic disturbances such as microcirculation disorders. These two approaches complement each other, providing an innovative perspective for the treatment of ARDS.
关键词
Keywords
references
LUCAS R , HADIZAMANI Y , ENKHBAATAR P , et al . Dichotomous role of tumor necrosis factor in pulmonary barrier function and alveolar fluid clearance [J]. Front Physiol , 2022 , 12 : 793251 . doi: 10.3389/fphys.2021. 793251 http://dx.doi.org/10.3389/fphys.2021.793251 .
MEYER N J , GATTINONI L , CALFEE C S . Acute respiratory distress syndrome [J]. Lancet , 2021 , 398 ( 10300 ): 622 - 637 .
ZHENG J , LI Y , KONG X , et al . Exploring immune-related pathogenesis in lung injury: providing new insights Into ALI/ARDS [J]. Biomed Pharmacother , 2024 , 175 : 116773 . doi: 10.1016/j.biopha.2024.116773 http://dx.doi.org/10.1016/j.biopha.2024.116773 .
LI B , LIU J , HE W , et al . Inhibition of macrophage inflammasome assembly and pyroptosis with GC-1 ameliorates acute lung injury [J]. Theranostics , 2025 , 15 ( 6 ): 2360 - 2374 .
DE SOUZA XAVIER COSTA N , DA COSTA SIGRIST G , SCHALCH A S , et al . Lung tissue expression of epithelial injury markers is associated with acute lung injury severity but does not discriminate sepsis from ARDS [J]. Respir Res , 2024 , 25 ( 1 ): 129 .
CAI Y , SHANG L , ZHOU F , et al . Macrophage pyroptosis and its crucial role in ALI/ARDS [J]. Front Immunol , 2025 , 16 : 1530849 . doi: 10.3389/fimmu.2025.1530849 http://dx.doi.org/10.3389/fimmu.2025.1530849 .
HALL S , FARIDI S , TRIVEDI P , et al . Cannabidiol reduces systemic immune activation in experimental acute lung injury [J]. Cannabis Cannabinoid Res , 2024 , 9 ( 5 ): 1301 - 1311 .
JIANG L , WANG M , SUN R , et al . Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7 [J]. Cell Biol Int , 2021 , 45 ( 8 ): 1666 - 1675 .
LI Y , JIANG Y , ZHANG H , et al . Research on acute lung injury inflammatory network [J]. Int J Clin Pharmacol Ther , 2023 , 61 ( 9 ): 394 - 403 .
SONG C , LI H , LI Y , et al . NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization [J]. Exp Cell Res , 2019 , 382 ( 2 ): 111486 .
LIU Y , WANG X , CHEN Y , et al . Pharmacological mechanisms of traditional Chinese medicine against acute lung injury: from active ingredients to herbal formulae [J]. Phytomedicine , 2024 , 135 : 155562 . doi: 10.1016/j.phymed.2024.155562 http://dx.doi.org/10.1016/j.phymed.2024.155562 .
AN Y , ZHANG H , WANG R , et al . Biomarkers, signa-ling pathways, and programmed cell death in acute lung injury and its treatment with traditional Chinese medicine: a narrative review [J]. Eur Rev Med Pharmacol Sci , 2023 , 27 ( 21 ): 10157 - 10170 .
PENG W , QI H , ZHU W , et al . Lianhua Qingke ameliorates lipopolysaccharide-induced lung injury by inhibi-ting neutrophil extracellular traps formation and pyroptosis [J]. Pulm Circ , 2023 , 13 ( 4 ): e12295 .
TIAN S , LIU T , JIANG J , et al . Salvia miltiorrhiza ameliorates endometritis in dairy cows by relieving inflammation, energy deficiency and blood stasis [J]. Front Pharmacol , 2024 , 15 : 1349139 . doi: 10.3389/fphar.2024. 1349139 http://dx.doi.org/10.3389/fphar.2024.1349139 .
ZHAO T , WANG L , ZHANG Y , et al . Qi-Dong-Huo-Xue-Yin balances the immune microenvironment to protect against LPS induced acute lung injury [J]. Front Pharmacol , 2023 , 14 : 1200058 . doi: 10.3389/fphar. 2023.1200058 http://dx.doi.org/10.3389/fphar.2023.1200058 .
YU Z Q , YU L , CHEN Y . Effectiveness and safety of Qidong Huoxue decoction in treatment of acute lung injury and acute respiratory distress syndrome: a randomized, controlled trial [J]. J Tradit Chin Med , 2024 , 44 ( 2 ): 381 - 387 .
Effect of Wei's Huoxue Tongluo Formula(韦氏活血通络方)on Visual Function and Fundus Blood Flow in Treating Atrophic-Stage Non-Arteritic Anterior Ischemic Optic Neuropathy with Qi Deficiency and Blood Stasis
Discussion on the Treatment of Acute Respiratory Distress Syndrome from the Theory of "Qi Loses Its Regulatory Function,Fluids and Blood Follow the Same Path"
Clinical Research and Basic Study on Effect of Huangqin Qingre Chubi Capsule (黄芩清热除痹胶囊) on Self-Perception of Patients and Immune Inflammation in Rheumatoid Arthritis
Effect of Modified Zhigancao Granules (炙甘草汤加味颗粒) on Early Recurrence Following Radiofrequency Ablation in Patients with Atrial Fibrillation of Qi-Yin Deficiency Syndrome:A Randomized,Double-Blind,Placebo-Controlled Trial
Effect of Ziyu Ointment (紫榆膏) on Postoperative Incisional Pain and Inflammatory Response by Regulating SDF-1/CXCR4 Pathway
Related Author
WANG Yan
CAO Linlin
HAO Meiling
SHUI Xiaoding
SONG Simin
DING Kun
ZHOU Rilong
LUO Yu
Related Institution
Beijing Jiangong Hospital
Dongfang Hospital,Beijing University of Chinese Medicine
Beijing University of Chinese Medicine
Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine
The First Affiliated Hospital of Anhui University of Chinese Medicine/Anhui Provincial Key Laboratory for Applied Basic and Clinical Translational Research of Traditional Chinese Medicine Rheumatology