Pathogenesis Evolution and Staged Differentiation and Treatment Strategy of Atherosclerotic Plaques:from the Perspective of "Constraint-Putrefaction-Ulceration"
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Pathogenesis Evolution and Staged Differentiation and Treatment Strategy of Atherosclerotic Plaques:from the Perspective of "Constraint-Putrefaction-Ulceration"
Journal of Traditional Chinese MedicineVol. 67, Issue 11, Pages: 1162-1166(2026)
WANG Hanzheng,LIU Zhihui,CHEN Hanlu,et al.Pathogenesis Evolution and Staged Differentiation and Treatment Strategy of Atherosclerotic Plaques:from the Perspective of "Constraint-Putrefaction-Ulceration"[J].Journal of Traditional Chinese Medicine,2026,67(11):1162-1166.
WANG Hanzheng,LIU Zhihui,CHEN Hanlu,et al.Pathogenesis Evolution and Staged Differentiation and Treatment Strategy of Atherosclerotic Plaques:from the Perspective of "Constraint-Putrefaction-Ulceration"[J].Journal of Traditional Chinese Medicine,2026,67(11):1162-1166.DOI: 10.13288/j.11-2166/r.2026.11.006.
Pathogenesis Evolution and Staged Differentiation and Treatment Strategy of Atherosclerotic Plaques:from the Perspective of "Constraint-Putrefaction-Ulceration"
Atherosclerotic plaques arise within the vessels, yet their morphological evolution parallels that of carbuncles and abscesses. Drawing on the pathomechanism progression of carbuncles and abscesses, this paper proposes a dynamic pathogenesis model of "constraint-putrefaction-ulceration" for atherosclerotic plaques. The formation of atherosclerotic plaque begins
with phlegm-turbidity obstruction and
qi
-blood stagnation (constraint stage); prolonged constraint transforms into heat that scorches the vessels and forms plaques (putrefaction stage); ultimately, toxin invades inward and ruptures the vessels, injuring the heart (ulceration stage). Accordingly, staged differentiation and treatments are proposed. During the constraint stage, the focus is venting constraint and unblocking collaterals, clearing and relieving constraint-heat, for which
Yue Jyu Pills
(越鞠丸) and
Danzhi Xiaoyao Powder
(丹栀逍遥散) with modifications can be used. During the putrefaction stage, the method is clearing heat and dispelling abscesses, resolving stasis and dissipating knot, with modified
Wuwei Xiaodu Beverage
(五味消毒饮) and
Xuefu Zhuyu Decoction
(血府逐瘀汤). During the ulceration stage, it is suggested to expell toxin and stasis, benefit
qi
and nourish
yin
using modified
Gualou Xiebai Banxia Decoction
(瓜蒌薤白半夏汤) and
Sheng Mai Powder
(生脉散). This framework offers new perspectives for the differentiation and treatment of atherosclerotic plaques in traditional Chinese medicine.
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references
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Analysis of Clinical and Phenomics Characteristics of Patients with Phlegm-Stasis Binding Syndrome and Its Accompanied Patterns in Stable Angina Pectoris of Coronary Heart Disease
Effects of Yangxin Tongmai Formula (养心通脉方) on Methylation Key Genes and the PERK/ATF4/CHOP Signaling Pathway in Myocardial Tissue of Coronary Heart Disease Model Rats with Blood Stasis Syndrome
Construction of a Diagnostic Model for Coronary Heart Disease with Blood Stasis Syndrome Based on Objective Multi-Modal Data Fusion
Expert Consensus on the Clinical Application of Jiuxin Pills (救心丸) in the Treatment of Coronary Heart Disease
Time Sequential Differentiation and Treatment of Atherosclerosis Under the Guidance of the Theory of "Accumulation in Pulse":Taking Coronary Heart Disease as An Example
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