Timing of Termination and Cost-Effectiveness Analysis of Acupuncture for Acute Peripheral Facial Paralysis：A Randomized Controlled Trial

ZHANG Xiaohan; WANG Tao; WANG Jinbo; MIAO Yiwen; DAI Lijuan; ZHANG Jiaying; WANG Shulan; WANG Hui; WANG Guoxin; CHEN Yuhang; WANG Xinjun; XU Bingguo

doi:10.13288/j.11-2166/r.2026.11.010

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Timing of Termination and Cost-Effectiveness Analysis of Acupuncture for Acute Peripheral Facial Paralysis：A Randomized Controlled Trial

更新时间：2026-05-29

- Timing of Termination and Cost-Effectiveness Analysis of Acupuncture for Acute Peripheral Facial Paralysis：A Randomized Controlled Trial
- Journal of Traditional Chinese Medicine Vol. 67, Issue 11, Pages: 1185-1191(2026)
- 作者机构：
  
  1.南京中医药大学，江苏省南京市栖霞区仙林大道138号，210023
  2.南京市第一医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2026.11.010
  CLC：
- Received：12 November 2025，
  
  Revised：2026-02-15，
  
  Accepted：12 February 2026，
  
  Published：02 June 2026
- 稿件说明：
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张晓涵,王焘,汪金波等.针刺治疗急性期周围性面瘫终止时机及成本效益分析的随机对照试验[J].中医杂志,2026,67(11):1185-1191.

ZHANG Xiaohan,WANG Tao,WANG Jinbo,et al.Timing of Termination and Cost-Effectiveness Analysis of Acupuncture for Acute Peripheral Facial Paralysis：A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(11):1185-1191.
张晓涵,王焘,汪金波等.针刺治疗急性期周围性面瘫终止时机及成本效益分析的随机对照试验[J].中医杂志,2026,67(11):1185-1191. DOI： 10.13288/j.11-2166/r.2026.11.010.

ZHANG Xiaohan,WANG Tao,WANG Jinbo,et al.Timing of Termination and Cost-Effectiveness Analysis of Acupuncture for Acute Peripheral Facial Paralysis：A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(11):1185-1191. DOI： 10.13288/j.11-2166/r.2026.11.010.

摘要

目的

探讨针刺治疗急性期周围性面瘫的适宜终止时机及成本效益。

方法

将120例急性期周围性面瘫患者随机分为轻度功能障碍终止组和完全恢复终止组各60例。两组均接受标准针刺方案治疗，轻度障碍终止组于Sunnybrook面神经功能（SFGS）评分首次≥83分时终止治疗，完全恢复终止组于SFGS评分首次≥95分时终止治疗。在治疗前、发病后6个月及12个月时进行SFGS评分、面部残疾指数（FDI）［包括躯体功能（FDIp）和社会生活功能（FDIs）］、焦虑自评量表（SAS）及抑郁自评量表（SDS）评分，记录治疗期间针刺相关任何不良事件进行安全性评价；记录治疗次数及医疗费用（包括直接费用、间接费用、医保支出、社会总费用及患者自付费用），并进行经济学评价［包括成本-效果比（CER）、增量成本-效果比（ICER）］。

结果

最终轻度障碍终止组56例、完全恢复终止组55例完成随访。治疗后两组患者在发病后6个月及12个月的SFGS评分、FDIp评分均高于本组治疗前，FDIs评分、SAS评分、SDS评分均低于本组治疗前（

＜0.05）。两组患者发病后6个月及12个月各评分组间比较，差异均无统计学意义（

＞0.05）。试验期间，轻度障碍终止组与完全恢复终止组不良事件发生率分别为13.3%（8/60）、18.3%（11/60），差异无统计学意义（

＞0.05）。轻度障碍终止组的治疗次数、社会总费用及患者自付费用均显著低于完全恢复终止组（

＜0.05）。轻度障碍终止组在SFGS、FDIp、FDIs、SAS、SDS评分的CER均低于完全恢复终止组。ICER结果表明，继续治疗至完全恢复，每多获得1分SFGS改善需多投入573.30元；而FDIp、FDIs、SAS、SDS每多改善1分，分别需多投入21 355.25元、1779.60元、3713.96元、2755.52元。

结论

针刺治疗急性期周围性面瘫选择轻度功能障碍终止时机，其远期疗效与完全恢复时终止相当，且能显著降低医疗费用及社会经济负担。

Abstract

Objective

To investigate the optimal termination time for acupuncture in treating patients with acute peripheral facial paralysis and its cost-effectiveness.

Methods

A total of 120 eligible patients with acute-stage peri-pheral facial paralysis were randomly assigned to either the mild dysfunction termination group and the complete recovery termination group， with 60 patients in each group. Both groups received the standard acupuncture treatment protocol. Treatment in the mild dysfunction termination group was terminated when the Sunnybrook facial grade scale （SFGS） score first reached or exceeded 83 points， while that in the complete recovery termination group was terminated when the SFGS score first reached or exceeded 95 points. Assessments were conducted before treatment， 6 and 12 months after onset. SFGS， facial disability index （FDI） including physical function （FDIp） and social function （FDIs）， self-rating anxiety scale （SAS）， and self-rating depression scale （SDS） scores were assessed before treatment， and 6 and 12 months after onset. Any acupuncture-related adverse events during treatment were recorded for safety evaluation. Treatment sessions and medical costs including direct costs， indirect costs， insurance coverage， total societal costs， and patient out-of-pocket expenses were also recorded， and an economic evaluation was conducted including cost-effectiveness ratio （CER） and incremental cost-effectiveness ratio （ICER）.

Results

Ultimately， 56 patients in the mild dysfunction termination group and 55 in the complete recovery termination group completed the follow-up. At 6 and 12 months after onset， SFGS and FDIp scores in both groups improved significantly while FDIs， SAS and SDS scores decreased （

＜0.05）. Comparison of scores between groups 6 months and 12 months after onset showed no statistically significant differences （

＞0.05）. During the trial， the incidence of adverse events was 13.3% （8/60） in the mild dysfunction termination group and 18.3% （11/60） in the complete rec

overy termination group， with no statistically significant difference （

＞0.05）. The number of treatment sessions， total social costs， and out-of-pocket expenses in the mild dysfunction termination group were significantly lower than those in the complete recovery termination group （

＜0.05）. The CER of the mild dysfunction termination group in SFGS， FDIp， FDIs， SAS， and SDS scores was lower than that of the complete recovery termination group. The ICER analysis showed that continuing treatment until full recovery incurred an additional cost of 573.30 CNY/point in SFGS improvement， whereas 1-point improvement in FDIp， FDIs， SAS， and SDS required 21

355.25 CNY， 1779.60 CNY， 3713.96 CNY， and 2755.52 CNY， respectively.

Conclusion

For acupuncture in treating acute peripheral facial palsy， terminating treatment when mild dysfunction is achieved yields long-term efficacy comparable to that of continuing treatment until complete recovery， while significantly reducing medical costs and socioeconomic burden.

关键词

Keywords

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