Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with <italic style="font-style: italic">Qi</italic> Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial

ZHAN Wenhao; DING Qian; DONG Zhiwei; LI Ting; FU Shumei; TIAN Ning

doi:10.13288/j.11-2166/r.2026.12.009

您当前的位置：

首页 >

文章列表页 >

Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with Qi Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial

更新时间：2026-06-12

- Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with Qi Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial
- Journal of Traditional Chinese Medicine Vol. 67, Issue 12, Pages: 1289-1296(2026)
- 作者机构：
  
  1.广州中医药大学附属广东中西医结合医院，广东省佛山市南海区桂城南五路16号，528200
  2.济南护理职业学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2026.12.009
  CLC：
- Received：07 January 2026，
  
  Revised：2026-04-15，
  
  Accepted：30 March 2026，
  
  Published：17 June 2026
- 稿件说明：
移动端阅览
湛文灏,丁倩,董志威等.热敏灸对气虚痰瘀型非小细胞肺癌化疗患者生活质量及免疫功能影响的随机对照试验[J].中医杂志,2026,67(12):1289-1296.

ZHAN Wenhao,DING Qian,DONG Zhiwei,et al.Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with Qi Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(12):1289-1296.
湛文灏,丁倩,董志威等.热敏灸对气虚痰瘀型非小细胞肺癌化疗患者生活质量及免疫功能影响的随机对照试验[J].中医杂志,2026,67(12):1289-1296. DOI： 10.13288/j.11-2166/r.2026.12.009.

ZHAN Wenhao,DING Qian,DONG Zhiwei,et al.Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with Qi Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(12):1289-1296. DOI： 10.13288/j.11-2166/r.2026.12.009.

摘要

目的

观察热敏灸对气虚痰瘀型非小细胞肺癌患者化疗后的生活质量和免疫功能的影响。

方法

70例气虚痰瘀型非小细胞肺癌患者随机分为干预组和对照组各35例。对照组采取化疗与常规对症治疗，干预组在对照组的基础上自化疗第1天开始予热敏灸治疗，取穴大椎、肺俞（双）、中脘、气海、关元，选取热敏灸感最强的部位作为施灸穴位，每次45 min，每周3次，治疗3周，共9次。治疗前后进行欧洲癌症研究与治疗组织生活质量问卷（EORTC QLQ-C30）评分、中医证候量表评分，检测外周血自然杀伤（NK）细胞、T淋巴细胞亚群水平（包括CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺）及程序性细胞死亡蛋白-1（PD-1）水平（包括PD-1⁺CD4⁺、PD-1⁺CD8⁺）。治疗前后检测两组患者肝肾功能并记录不良事件发生情况。

结果

干预组有1例脱落、1例剔除，对照组有2例脱落，最终两组各33例纳入分析。与本组治疗前比较，干预组患者治疗后躯体功能、角色功能、情绪功能、认知功能、社会功能及总体健康状况评分均升高，疲倦、恶心呕吐、气促、食欲丧失、腹泻评分及中医证候量表评分均降低（

＜0.05）；且治疗后干预组躯体功能、角色功能、总体健康状况评分高于对照组，疲倦、恶心呕吐、气促、食欲丧失、腹泻评分和中医证候量表评分低于对照组（

＜0.05）。治疗后干预组患者外周血NK细胞、PD-1⁺CD8⁺水平较治疗前明显增加，且干预组外周血NK细胞水平高于对照组，PD-1⁺CD8⁺水平低于对照组（

＜0.05）。两组

患者肝肾功能指标治疗前后比较差异均无统计学意义（

＞0.05），均未发生烫伤、晕灸等不良事件。

结论

热敏灸辅助治疗气虚痰瘀型非小细胞肺癌患者具有增强免疫功能、改善临床症状、提高生活质量的优势，且安全性较好。

Abstract

Objective

To observe the effect of heat-sensitive moxibustion on quality of life and immune function in non-small cell lung cancer （NSCLC） patients undergoing chemotherapy.

Methods

Seventy NSCLC patients with

deficiency and phlegm stasis syndrome were randomly divided into an intervention group and a control group， with 35 cases in each group. The control group received chemotherapy combined with routine symptomatic treatment， while the intervention group additionally received heat-sensitive moxibustion since the first day of chemotherapy. Acupoints included Dazhui （GV14）， bilateral Feishu （BL13）， Zhongwan （CV12）， Qihai （CV6）， and Guanyuan （CV4）. The site exhibiting the strongest heat-sensitization response was selected for moxibustion. Treatment was administered for 45 minutes per session， three times weekly for three consecutive weeks， totaling nine sessions. Before and after treatment， quality of life was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire （EORTC QLQ-C30）， and traditional Chinese medicine （TCM） syndrome scores were evaluated. Peripheral blood levels of natural killer （NK） cells and T-lymphocyte subsets including CD3

， CD4

， and CD8

， and CD4

/CD8

ratio were measured. Levels of programmed cell death protein-1 （PD-1）， including PD-1⁺CD4⁺ and PD-1⁺CD8⁺ cells， were also assessed. Liver and renal function were monitored before and after treatment， and adverse events were recorded.

Results

In the intervention group， 1 participant withdrew and 1 was excluded， while in the control group， 2 participants withdrew. Ultimately， 33 participants in each group were inclu

ded in the final analysis. The intervention group showed significant improvements in physical， role， emotional， cognitive， and social functioning， as well as global health status after treatment， while scores for fatigue， nausea and vomiting， dyspnea， appetite loss， diarrhea， and TCM syndrome scale were significantly decreased （

＜0.05）. Moreover， the intervention group demonstrated higher scores in physical functioning， role functioning， and global health status， as well as lower scores for fatigue， nausea and vomiting， dyspnea， appetite loss， diarrhea， and the TCM syndrome scale than the control group （

＜0.05）. After treatment， the levels of peripheral NK cells and PD-1⁺CD8⁺ T cells in the intervention group increased significantly； furthermore， the intervention group exhibited higher peripheral NK cell levels and lower PD-1⁺CD8⁺ T cell levels than the control group （

＜0.05）. No significant differences were found in liver or renal function between the two groups （

＞0.05）. In addition， no adverse events such as burns or moxibustion-induced syncope occurred during the study.

Conclusion

Heat-sensitive moxibustion as an adjunctive therapy may enhance immune function， alleviate clinical symptoms， and improve quality of life， while demonstrating a favorable safety profile in NSCLC patients with

deficiency and phlegm stasis.

关键词

Keywords

references

BRAY F ， LAVERSANNE M ， SUNG H ， et al . Global cancer statistics 2022： GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries ［J］. CA Cancer J Clin ， 2024 ， 74 （ 3 ）： 229 - 263 .

MALHOTRA J ， JABBOUR S K ， AISNER J . Current state of immunotherapy for non-small cell lung cancer ［J］. Transl Lung Cancer Res ， 2017 ， 6 （ 2 ）： 196 - 211 .

QI L ， LUO Q ， ZHANG Y ， et al . Advances in toxicological research of the anticancer drug cisplatin ［J］. Chem Res Toxicol ， 2019 ， 32 （ 8 ）： 1469 - 1486 .

曹洋 . 晚期非小细胞肺癌的中医证候规律研究［J］. 中华中医药学刊， 2011 ， 29 （ 4 ）： 754 - 757 .

刘文瑞，冯贞贞，李建生 . 基于文献的不同分期非小细胞肺癌患者中医证候、证素分布规律研究［J］. 中医杂志， 2021 ， 62 （ 18 ）： 1635 - 1639 .

丁坤，门晓冰，王翠，等 . 热敏灸对恶性肿瘤患者化疗后骨髓抑制的预防效果研究［J］. 中国实用医药， 2023 ， 18 （ 22 ）： 114 - 117 .

周梅，杨硕，陈日新，等 . 热敏灸联合盐酸托烷司琼治疗化疗相关性恶心呕吐：随机对照试验［J］. 中国针灸， 2024 ， 44 （ 5 ）： 531 - 536 .

吴锦燕，吴薏婷 . 恶性肿瘤患者化疗后行热敏灸对骨髓抑制的预防效果［J］. 中国当代医药， 2017 ， 24 （ 20 ）： 76 - 78 .

FAYERS P M . Interpreting quality of life data： population-based reference data for the EORTC QLQ-C30 ［J］. Eur J Cancer ， 2001 ， 37 （ 11 ）： 1331 - 1334 .

颜虹，徐勇勇，赵耐青 . 医学统计学［M］. 北京：人民卫生出版社， 2010 ： 277 - 280 .

中华医学会肿瘤学分会，中华医学会杂志社 . 中华医学会肺癌临床诊疗指南（2023版）［J］. 中华医学杂志， 2023 ， 103 （ 27 ）： 2037 - 2074 .

郑筱萸 . 中药新药临床研究指导原则（试行）［M］. 北京：中国医药科技出版社， 2002 ： 57 - 58 .

SCHAG C C ， HEINRICH R L ， GANZ P A . Karnofsky performance status revisited： reliability， validity， and guidelines ［J］. J Clin Oncol ， 1984 ， 2 （ 3 ）： 187 - 193 .

陈日新，陈明人，康明非 . 热敏灸实用读本［M］. 北京：人民卫生出版社， 2009 ： 3 - 22 .

RAMI-PORTA R ， NISHIMURA K K ， GIROUX D J ， et al . The International Association for the Study of Lung Cancer Staging Project： proposals for revision of the TNM stage groups in the forthcoming ninth edition of the TNM classification for lung cancer ［J］. J Thorac Oncol ， 2024 ， 19 （ 7 ）： 1007 - 1027 .

袁伟琛，夏蕾，张杰翔 . 浊毒理论在化疗相关性腹泻中的应用探析［J］. 中国中西医结合消化杂志， 2022 ， 30 （ 10 ）： 753 - 757 .

SHI J ， ZHANG X ， CHEN J ， et al . Acupuncture and moxibustion therapy for cognitive impairment： the microbiome-gut-brain axis and its role ［J］. Front Neurosci ， 2024 ， 17 ： 1275860 . doi： 10.3389/fnins.2023.1275860. eCollection 2023 http://dx.doi.org/10.3389/fnins.2023.1275860.eCollection2023 .

BINNEWIES M ， ROBERTS E W ， KERSTEN K ， et al . Understanding the tumor immune microenvironment （TIME） for effective therapy ［J］. Nat Med ， 2018 ， 24 （ 5 ）： 541 - 550 .

KRASNOVA Y ， PUTZ E M ， SMYTH M J ， et al . Bench to bedside： NK cells and control of metastasis ［J］. Clin Immunol ， 2017 ， 177 ： 50 - 59 . doi： 10.1016/j.clim.2015. 10.001 http://dx.doi.org/10.1016/j.clim.2015.10.001 .

CHIOSSONE L ， DUMAS P ， VIENNE M ， et al . Natural killer cells and other innate lymphoid cells in cancer ［J］. Nat Rev Immunol ， 2018 ， 18 （ 11 ）： 671 - 688 .

TAO J H ， ZHANG J ， LI H S ， et al . Nature killer cell for solid tumors： current obstacles and prospective remedies in NK cell therapy and beyond ［J］. Crit Rev Oncol Hematol ， 2025 ， 205 ： 104553 . doi： 10.1016/j.critrevonc. 2024.104553 http://dx.doi.org/10.1016/j.critrevonc.2024.104553 .

MCKINNEY E F ， SMITH K G . T cell exhaustion and immune-mediated disease-the potential for therapeutic exhaustion ［J］. Curr Opin Immunol ， 2016 ， 43 ： 74 - 80 . doi： 10.1016/j.coi.2016.09.005 http://dx.doi.org/10.1016/j.coi.2016.09.005 .

DAI S ， REN P ， REN J ， et al . The relationship between lymphocyte subsets and the prognosis and genomic features of lung cancer： a retrospective study ［J］. Int J Med Sci ， 2021 ， 18 （ 10 ）： 2228 - 2234 .

MONTAUTI E ， OH D Y ， FONG L . CD4 + T cells in antitumor immunity ［J］. Trends Cancer ， 2024 ， 10 （ 10 ）： 969 - 985 .

袁飞，王新乐，张灿，等 . NSCLC肿瘤及癌旁组织CD4 + 和CD8 + T细胞PD-1的表达及意义［J］. 安徽医科大学学报， 2019 ， 54 （ 8 ）： 1295 - 1298 .

周晓慧，王莉，朱华渊，等 . 外周血CD4 + T淋巴细胞绝对数及CD4 + /CD8 + 比值在套细胞淋巴瘤中的预后价值［J］. 南京医科大学学报（自然科学版）， 2019 ， 39 （ 4 ）： 520 - 527 .

RAJAPPA S ， SHARMA S ， PRASAD K . Unmet clinical need in the management of locally advanced unresectable lung cancer： treatment strategies to improve patient outcomes ［J］. Adv Ther ， 2019 ， 36 （ 3 ）： 563 - 578 .

VERDON D J ， MULAZZANI M ， JENKINS M R . Cellular and molecular mechanisms of CD8 + T cell differentiation， dysfunction and exhaustion ［J］. Int J Mol Sci ， 2020 ， 21 （ 19 ）： 7357 .

钟玉梅，吴菲，罗小超，等 . 基于PD-1/PD-L1信号通路艾灸治疗类风湿性关节炎的机制研究［J］. 中国针灸， 2020 ， 40 （ 9 ）： 976 - 982 .

熊罗节，田岳凤，徐小珊，等 . 隔药饼灸对免疫抑制兔Tim-4及PD-1的泛素化的影响［J］. 中国针灸， 2023 ， 43 （ 5 ）： 529 - 536 .

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Optimized New Shengmai Powder （优化新生脉散方） on Exercise Tolerance in Patients with Chronic Heart Failure of Qi Deficiency，Blood Stasis and Fluid Retention Syndrome：A Randomized，Double-Blind，Placebo-Controlled Trial

Zipi Zengye Formula （滋脾增液方） for the Treatment of Functional Constipation with Deficiency of Both Qi and Yin：A Randomised Controlled

Effect of Modified Lurong Sancao Decoction （鹿蓉三草汤） on Quality of Life and Immune Function in Differentiated Thyroid Cancer Patients after Surgery：A Randomized Controlled Trial

Effects of Modified Guomin Decoction （加味过敏煎） on Traditional Chinese Medicine Syndromes and Quality of Life in Patients with Mild to Moderate Atopic Dermatitis of Heart Fire and Spleen Deficiency Pattern：A Randomized，Double-Blind，Placebo-Controlled Trial

The Effect and Safety of Zizao Yangrong Granules （滋燥养荣颗粒） for EGFRIs-related Skin Xerosis with Yin Deficiency and Blood Dryness Pattern： A Long-term Follow-up Study

Related Author

WANG Xianliang

ZHANG Jingyi

GE Zhao

LIU Tongzuo

ZHANG Maozhe

WANG Shuai

ZHAO Zhiqiang

BI Yingfei

Related Institution

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/ National Clinical Research Center for Chinese Medicine

Tianjin University of Traditional Chinese Medicine

Shuguang Hospital，Shanghai University of Traditional Chinese Medicine

The First Affiliated Hospital of Shihezi University

The People's Hospital of Shihezi

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with Qi Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial

DOI：10.13288/j.11-2166/r.2026.12.009

摘要

Abstract

关键词

Keywords

references