Acupuncture Treatment for Severe Bell's Palsy and Its Impact on Serum GDNF and NGF：A Randomized Controlled Trial

MA Li; LI Xiaonan; SU Chenyang; FENG Juanjuan; LIU Jingyi; QIAO Haoyi; BAI Peng

doi:10.13288/j.11-2166/r.2026.12.010

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Acupuncture Treatment for Severe Bell's Palsy and Its Impact on Serum GDNF and NGF：A Randomized Controlled Trial

更新时间：2026-06-12

- Acupuncture Treatment for Severe Bell's Palsy and Its Impact on Serum GDNF and NGF：A Randomized Controlled Trial
- Journal of Traditional Chinese Medicine Vol. 67, Issue 12, Pages: 1297-1304(2026)
- 作者机构：
  
  1.北京中医药大学第三附属医院，北京市朝阳区安外小关街51号，100029
  2.北京中医药大学东直门医院
  3.北京中医药大学针灸推拿学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2026.12.010
  CLC：
- Received：27 February 2026，
  
  Revised：2026-05-19，
  
  Accepted：30 March 2026，
  
  Published：17 June 2026
- 稿件说明：
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马莉,李笑楠,苏晨阳等.针刺治疗重度Bell麻痹的临床疗效评价及对血清GDNF、NGF的影响——一项随机对照试验[J].中医杂志,2026,67(12):1297-1304.

MA Li,LI Xiaonan,SU Chenyang,et al.Acupuncture Treatment for Severe Bell's Palsy and Its Impact on Serum GDNF and NGF：A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(12):1297-1304.
马莉,李笑楠,苏晨阳等.针刺治疗重度Bell麻痹的临床疗效评价及对血清GDNF、NGF的影响——一项随机对照试验[J].中医杂志,2026,67(12):1297-1304. DOI： 10.13288/j.11-2166/r.2026.12.010.

MA Li,LI Xiaonan,SU Chenyang,et al.Acupuncture Treatment for Severe Bell's Palsy and Its Impact on Serum GDNF and NGF：A Randomized Controlled Trial[J].Journal of Traditional Chinese Medicine,2026,67(12):1297-1304. DOI： 10.13288/j.11-2166/r.2026.12.010.

摘要

目的

观察针刺治疗重度Bell麻痹的临床疗效与安全性，并从血清胶质细胞源性神经营养因子（GDNF）及神经生长因子（NGF）水平探讨其可能作用机制。

方法

采用随机、受试者盲法、安慰针对照的试验设计，纳入130例重度Bell麻痹患者，随机分为试验组和对照组各65例。两组在西药基础治疗的同时，试验组给予针刺治疗，对照组给予安慰针，每次30 min。两组疗程均为8周，于第12周进行随访。主要观察指标为第8周House-Brackmann面神经功能分级（H-B分级）Ⅱ级及以下的患者比例。次要观察指标包括第0、4、8、12周时Sunnybrook面神经评定系统评分；面部恢复至达到满意恢复的时间，即H-B分级为Ⅱ级及以下所需的时间；第0、4、8、12周时H-B分级分布情况、面部残疾指数（FDI）评分［包括躯体功能（FDIP）、社会生活功能（FDIS）］；治疗第0、4、8周时血清GDNF、NGF因子水平。记录不良事件及受试者自我疗效评估。

结果

最终共完成研究122例，试验组62例，对照组60例。采用意向性分析方法，取末次观测值结转法对缺失值进行处理。第8周试验组H-B分级在Ⅱ级及以下的患者占78.5%（51/65），对照组占49.2%（32/65），试验组显著高于对照组（

＜0.05）。与本组第0周时比较，第4、8、12周时两组Sunnybrook评分、FDIP评分、FDIS评分升高，H-B分级降低，且试验组各指标改善均优于对照组（

＜0.05）。试验组患者满意中位恢复时间为6周（95%

：5.697，6.303），对照组为12周（95%

：8.314，15.686），试验组快于对照组（

＜0.05）。试验组第4、8周时血清GDNF、NGF因子水平均高于对照组（

＜0.05）。治疗期间两组均未发生与针刺相关的严重不良事件，试验组发生不良事件5例（5/65，7.69%），对照组4例（4/65，6.15%），两组比较差异无统计学意义（

＞0.05）。第8周治疗结束后受试者对治疗效果的自我评估，试验组优于对照组（

＜0.05）。

结论

针刺可改善重度Bell麻痹患者的面神经功能，缩短恢复时间，且安全性良好。其作用机制可能与提高血清GDNF、NGF因子水平有关。

Abstract

Objective

To evaluate the clinical efficacy and safety of acupuncture in treating severe Bell's palsy and to explore its potential mechanism by investigating the effect on serum levels of glial cell line-derived neurotrophic factor （GDNF） and nerve growth factor （NGF）.

Methods

A randomized， subject-blinded， sham-acupuncture controlled trial was conducted. A total of 130 patients with severe Bell's palsy were randomly allocated into a treatment group or a control group at a 1∶1 ratio. Both groups received conventional western medicine. In addition， the treatment group received acupuncture， while the control group received sham acupuncture， with each session lasting 30 minutes. The treatment course lasted 8 weeks for both groups， followed by a follow-up assessment at week 12. The primary outcome was the proportion of patients achieving House-Brackmann （H-B） grade Ⅱ or lower at week 8. Secondary outcomes included Sunnybrook facial grading system scores at week 0， 4， 8， and 12， the time to satisfactory recovery（the time required to achieve H-B grade≤Ⅱ）， distribution of H-B grades and facial disability index （FDI） scores including the physical function subscale （FDIP） and social/well-being function subscale （FDIS） scores at week 0， 4， 8， and 12， and serum GDNF and NGF levels at week 0， 4， and 8. Adverse events and participants' self-assessments of treatment efficacy were also recorded.

Results

A total of 122 participants completed the study， including 62 in the treatment group and 60 in the control group. An intention-to-treat （ITT） analysis was performed， and missing data were handled using the last observation carried forward （LOCF） method. The proportion of patients achieving H-B grade ≤grade Ⅱ at week 8 was 78.5% （51/65） in the treatment group， significantly higher than 49.2% （32/65） in the control group （

＜0.05）. The Sunnybrook scores， FDIP and FDIS scores increased， while H-B grades decreased at week 4， 8， and 12 in both groups compared to week 0； moreover， improvements in all outcome measures were significantly greater in the treatment group than in the control group （

＜0.05）. The median time to satisfactory recovery was 6 weeks （95%

： 5.697-6.303） in the treatment group， significantly shorter than 12 weeks （95%

： 8.314-15.686） in the control group （

＜0.05）. Serum levels of GDNF and NGF were significantly higher in the treatment group at weeks 4 and 8 （

＜0.05）. No serious acupuncture-related adverse events occurred in either group. Adverse events were reported in 5 patients （7.69%） in the treatment group and 4 patients （6.15%） in the control group， with no statistically significant difference between groups （

＞0.05）. Patients' self-assessment of treatment efficacy after 8 weeks treatment was significantly better in the treatment group （

＜0.05）.

Conclusion

Acupuncture can effectively improve facial nerve function and shorten recovery time in patients with severe Bell's palsy， with a favorable safety profile. The therapeutic mechanism may be associated with the upregulation of serum GDNF and NGF levels.

关键词

Keywords

references

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