Professor ZHOU Shaohua's Experience in Staged Treatment of Parkinson's Disease Based on the "Disease-Symptom-Syndrome Integration" Approach

XU Dinglin; WANG Jiayi; GE Liwei; GUO Chunli

doi:10.13288/j.11-2166/r.2026.13.004

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Professor ZHOU Shaohua's Experience in Staged Treatment of Parkinson's Disease Based on the "Disease-Symptom-Syndrome Integration" Approach

更新时间：2026-06-29

- Professor ZHOU Shaohua's Experience in Staged Treatment of Parkinson's Disease Based on the "Disease-Symptom-Syndrome Integration" Approach
- Journal of Traditional Chinese Medicine Vol. 67, Issue 13, Pages: 1373-1377(2026)
- 作者机构：
  
  1.中国中医科学院西苑医院，北京市海淀区西苑操场1号，100091
  2.北京中医药大学研究生院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2026.13.004
  CLC：
- Received：30 March 2026，
  
  Revised：2026-05-18，
  
  Accepted：17 May 2026，
  
  Published：02 July 2026
- 稿件说明：
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徐丁林,王嘉仪,葛力维等.周绍华“病、症、证结合”分期论治帕金森病经验[J].中医杂志,2026,67(13):1373-1377.

XU Dinglin,WANG Jiayi,GE Liwei,et al.Professor ZHOU Shaohua's Experience in Staged Treatment of Parkinson's Disease Based on the "Disease-Symptom-Syndrome Integration" Approach[J].Journal of Traditional Chinese Medicine,2026,67(13):1373-1377.
徐丁林,王嘉仪,葛力维等.周绍华“病、症、证结合”分期论治帕金森病经验[J].中医杂志,2026,67(13):1373-1377. DOI： 10.13288/j.11-2166/r.2026.13.004.

XU Dinglin,WANG Jiayi,GE Liwei,et al.Professor ZHOU Shaohua's Experience in Staged Treatment of Parkinson's Disease Based on the "Disease-Symptom-Syndrome Integration" Approach[J].Journal of Traditional Chinese Medicine,2026,67(13):1373-1377. DOI： 10.13288/j.11-2166/r.2026.13.004.

摘要

总结周绍华教授“病、症、证结合”分期论治帕金森病的临证经验。认为肾精亏虚为发病之本，痰瘀蕴毒为恶化之关键。将帕金森病分为前驱期、早期及中晚期。前驱期治疗以补肾填髓为本，选用左归丸或右归丸，并针对便秘、快速眼动睡眠行为障碍等非运动症状随症加减；早期辨证分为肝肾阴虚风动、脾肾阳虚、痰浊壅盛三型，主张“治风先治血”，分别以大定风珠、右归丸、金水六君煎为基础方，合用四物汤养血熄风；中晚期补肾固元与解毒化浊并举，加鹿角胶、龟甲等血肉有情之品，联合黄连解毒汤清热解毒化浊、攻补兼施，重视体位性低血压、吞咽困难等非运动症状的中西医协同调治。

Abstract

This paper aims to summarize Professor ZHOU Shaohua's clinical experience in treating Parkinson's disease （PD） based on the "disease-symptom-syndrome integration" approach. It is believed that kidney essence deficiency is the root cause of the disease， and phlegm-stasis accumulating toxin is the key factor for its deterioration. PD could be divided into the prodromal stage， early stage and middle-late stage. In the prodromal stage， treatment focuses on tonifying the kidney and replenishing marrow， choosing

Zuogui Pill

（左归丸） or

Yougui Pill

（右归丸） to prescribe with modifications according to accompanying non-motor symptoms such as constipation and rapid eye movement sleep behavior disorder. For the early stage， the disease is differentiated into three syndromes， liver-kidney

yin

deficiency with stirring wind， spleen-kidney

yang

deficiency， and excessive phlegm turbidity， then following the principle of "calming wind by regulat

ing blood first"， the basic prescriptions of

Dading Fengzhu Pill

（大定风珠），

Yougui Pill

（右归丸） and

Jinshui Liujun Decoction

（金水六君煎） are applied respectively， combined with

Siwu Decoction

（四物汤） to nourish blood and extinguish wind. For the middle-late stage， therapies of tonifying the kidney and conso-lidating original

are combined with detoxifying and resolving turbidity， prescribing fleshy and nourishing medicinals such as deer-horn glue （

Cervus nippon Temminck

） and turtle shell glue （

Colla Carapacis et Plastri Testudinis

）， together with

Huanglian Jiedu Decoction

（黄连解毒汤） to clear heat， detoxify and resolve turbidity， implementing simultaneous tonification and elimination. Integrated traditional Chinese and western medicine intervention is emphasized for non-motor symptoms including orthostatic hypotension and dysphagia.

关键词

Keywords

references

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