Exploration of the Pathogenesis and Syndrome-Based Treatment of Functional Constipation Based on the Theory of "Heavy Obstruction and Orifice Blockage"
|更新时间:2026-08-05
|
Exploration of the Pathogenesis and Syndrome-Based Treatment of Functional Constipation Based on the Theory of "Heavy Obstruction and Orifice Blockage"
Journal of Traditional Chinese MedicineVol. 67, Issue 15, Pages: 1659-1663(2026)
SHI Haoran,LIANG Kexin,ZHI Jing,et al.Exploration of the Pathogenesis and Syndrome-Based Treatment of Functional Constipation Based on the Theory of "Heavy Obstruction and Orifice Blockage"[J].Journal of Traditional Chinese Medicine,2026,67(15):1659-1663.
SHI Haoran,LIANG Kexin,ZHI Jing,et al.Exploration of the Pathogenesis and Syndrome-Based Treatment of Functional Constipation Based on the Theory of "Heavy Obstruction and Orifice Blockage"[J].Journal of Traditional Chinese Medicine,2026,67(15):1659-1663.DOI: 10.13288/j.11-2166/r.2026.15.013.
Exploration of the Pathogenesis and Syndrome-Based Treatment of Functional Constipation Based on the Theory of "Heavy Obstruction and Orifice Blockage"
Based on LI Gao's theory of "heavy obstruction" and "blockage of the nine orifices", this paper proposes the pathological concept of "heavy obstruction and orifice blockage". It is suggested that the core pathogenesis of functional constipation (FC) lies in simultaneous sinking of spleen and lung, together with accumulation and obstruction of dampness and turbidity, resulting in impaired movement of intestinal
qi
. Within this framework, spleen deficiency with sinking of dampness is considered as the primary pathological mechanism of outlet obstructive constipation (OOC), while sinking of lung
qi
is regarded as the key mechanism underlying slow transit constipation (STC). When both pathological mechanisms coexist, mixed constipation (MC) develops. Guided by this theory, FC is classified into three patterns for syndrome-based treatment. OOC is treated by promoting bowel movement, descending turbid pathogens, and opening the orifices to restore function, with self-formulated
Shengxian Tongqiao Decoction
(升陷通窍汤). STC is treated by diffusing lung
qi
, regulating spleen function, raising sinking
qi
, an
d promoting transportation, with self-formulated
Xuanfei Yunpi Decoction
(宣肺运脾汤). MC is treated by regulating lung and spleen function, simultaneously raising clear
qi
and descending turbidity, with self-formulated
Xuanyun Tongqiao Decoction
(宣运通窍汤). In clinical practice, modifications should be made according to accompanying syndromes and individual conditions.
Barberio B , Judge C , Savarino E V , et al . Global prevalence of functional constipation according to the Rome criteria: a systematic review and meta-analysis [J]. Lancet Gastroenterol Hepatol , 2021 , 6 ( 8 ): 638 - 648 .
Aziz I , Whitehead W E , Palsson O S , et al . An approach to the diagnosis and management of Rome Ⅳ functional disorders of chronic constipation [J]. Expert Rev Gastroenterol Hepatol , 2020 , 14 ( 1 ): 39 - 46 .
Yüksel İ , Baş M , Özdemir M , et al . Obstructed defecation syndrome [J]. Turk J Colorectal Dis , 2021 , 31 ( 2 ): 88 - 98 .
Rao S S C . Dyssynergic defecation and biofeedback the-rapy [J]. Gastroenterol Clini N , 2008 , 37 ( 3 ): 569 - 586 .
Wang H , Ren B , Pan J , et al . Effect of miR-129-3p on autophagy of interstitial cells of Cajal in slow transit constipation through SCF C-kit signaling pathway [J]. Acta Biochimica Polonica , 2022 , 69 ( 3 ): 579 - 586 .
Fei X , He Q , Wang S , et al . Leven PRO-CR mediates 5-HT and gut microbiota via TPH1 to improve slow-transit constipation [J]. Mol Immunol , 2025 , 185 : 81 - 91 . DOI: 10.1016/j.molimm.2025.07.007 http://dx.doi.org/10.1016/j.molimm.2025.07.007 .