WU Mianhua's Experience in Staged Treatment of Radiation-Induced Brain Injury Based on the Theory of Stasis-Heat

SHEN Xingkang; YUAN Weichen; DING Jiping; ZHOU Hongguang

doi:10.13288/j.11-2166/r.2026.20.003

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WU Mianhua's Experience in Staged Treatment of Radiation-Induced Brain Injury Based on the Theory of Stasis-Heat

更新时间：2026-10-10

- WU Mianhua's Experience in Staged Treatment of Radiation-Induced Brain Injury Based on the Theory of Stasis-Heat
- Journal of Traditional Chinese Medicine Vol. 67, Issue 20, Pages: 2161-2165(2026)
- 作者机构：
  
  1.南京中医药大学附属医院，江苏省南京市秦淮区汉中路155号，210029
  2.南京中医药大学第一临床医学院
  3.江苏省中医药防治肿瘤协同创新中心
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2026.20.003
  CLC：
- Received：18 April 2026，
  
  Revised：2026-09-14，
  
  Accepted：03 July 2026，
  
  Published：17 October 2026
- 稿件说明：
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沈兴康,袁伟琛,丁吉平等.吴勉华从瘀热分期论治放射性脑损伤经验[J].中医杂志,2026,67(20):2161-2165.

SHEN Xingkang,YUAN Weichen,DING Jiping,et al.WU Mianhua's Experience in Staged Treatment of Radiation-Induced Brain Injury Based on the Theory of Stasis-Heat[J].Journal of Traditional Chinese Medicine,2026,67(20):2161-2165.
沈兴康,袁伟琛,丁吉平等.吴勉华从瘀热分期论治放射性脑损伤经验[J].中医杂志,2026,67(20):2161-2165. DOI： 10.13288/j.11-2166/r.2026.20.003.

SHEN Xingkang,YUAN Weichen,DING Jiping,et al.WU Mianhua's Experience in Staged Treatment of Radiation-Induced Brain Injury Based on the Theory of Stasis-Heat[J].Journal of Traditional Chinese Medicine,2026,67(20):2161-2165. DOI： 10.13288/j.11-2166/r.2026.20.003.

摘要

总结吴勉华教授从瘀热分期论治放射性脑损伤（RIBI）的临证经验。认为RIBI以放射火毒为始动因素，核心病机为瘀热相搏、风痰阻络、气阴两虚、精伤髓减。早期以瘀热水结、风痰阻络为主，病入脑络，治以凉血散瘀、熄风通络，兼以化痰利水，选用自拟凉血通络方；中期以痰瘀热互结、肾精耗伤为要，病及肾精，治以豁痰祛瘀、清解伏热、填精益髓，选用自拟清化填精方；晚期多见气阴两虚、毒损髓竭，病达脑髓，治以益气养阴、解毒补髓，选用自拟养阴解毒方。

Abstract

This paper summarizes Professor WU Mianhua's clinical experience in the staged treatment of radiation-induced brain injury （RIBI） based on the stasis-heat theory. It is believed that radiation fire-toxin is the initiating pathogenic factor of RIBI， a

nd the core pathogenesis consists of the intermingling of stasis and heat， obstruction of collaterals by wind-phlegm， dual deficiency of

and

yin

， as well as impairment of essence and depletion of marrow. In the early stage， the disease is mainly manifested as stasis-heat with fluid retention and obstruction of collaterals by wind-phlegm， with the lesion located in the brain collaterals. The therapeutic principle is to cool the blood and dissipate stasis， extinguish wind and unblock collaterals， and simultaneously eliminate phlegm and promote urination， according to which self-designed

Liangxue Tongluo Formula

（凉血通络方） is selected for treatment.In the middle stage， the key pathological features are the binding of phlegm， stasis and heat， and consumption of kidney essence， with the lesion invading the kidney essence. The therapeutic principle is to resolve phlegm and remove stasis， clear and relieve latent heat， replenish essence and tonify marrow， and the self-designed

Qinghua Tianjing Formula

（清化填精方） is selected for treatment. In the advanced stage， the disease is mostly manifested as dual deficiency of

and

yin

and toxin-induced marrow exhaustion， with the lesion involving the brain marrow. The therapeutic principle is to replenish

and nourish

yin

， remove toxin and tonify marrow， and the self-designed

Yangyin Jiedu Formula

（养阴解毒方） is selected for treatment.

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references

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