A Cross-Sectional Study on the Distribution of Traditional Chinese Medicine Constitutions and Factors Associated with Hyperuricemia

ZHANG Zhongyi; LI Fangli; HU Shiping; AN Shujie; ZHU Xihuan; ZHANG Jiahui; JIN Luyao; ZONG Yuhan; ZHOU Mengru; WANG Ji; WANG Huaiyu; WANG Qi

doi:10.13288/j.11-2166/r.2026.20.011

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A Cross-Sectional Study on the Distribution of Traditional Chinese Medicine Constitutions and Factors Associated with Hyperuricemia

更新时间：2026-10-10

- A Cross-Sectional Study on the Distribution of Traditional Chinese Medicine Constitutions and Factors Associated with Hyperuricemia
- Journal of Traditional Chinese Medicine Vol. 67, Issue 20, Pages: 2210-2218(2026)
- 作者机构：
  
  1.北京中医药大学王琦书院/国家中医体质与治未病研究院，北京市朝阳区北三环东路11号，100029
  2.北京中医药大学中医学院
  3.北京中医药大学深圳医院（龙岗）
  4.空军军医大学第一附属医院（西京医院）
  5.北京中医药大学岐黄学院
  6.广州中医药大学第二临床医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2026.20.011
  CLC：
- Received：26 November 2025，
  
  Revised：2026-08-16，
  
  Accepted：20 April 2026，
  
  Published：17 October 2026
- 稿件说明：
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张中意,李芳莉,胡世平等.高尿酸血症患者中医体质分布特点及患病相关因素的横断面研究[J].中医杂志,2026,67(20):2210-2218.

ZHANG Zhongyi,LI Fangli,HU Shiping,et al.A Cross-Sectional Study on the Distribution of Traditional Chinese Medicine Constitutions and Factors Associated with Hyperuricemia[J].Journal of Traditional Chinese Medicine,2026,67(20):2210-2218.
张中意,李芳莉,胡世平等.高尿酸血症患者中医体质分布特点及患病相关因素的横断面研究[J].中医杂志,2026,67(20):2210-2218. DOI： 10.13288/j.11-2166/r.2026.20.011.

ZHANG Zhongyi,LI Fangli,HU Shiping,et al.A Cross-Sectional Study on the Distribution of Traditional Chinese Medicine Constitutions and Factors Associated with Hyperuricemia[J].Journal of Traditional Chinese Medicine,2026,67(20):2210-2218. DOI： 10.13288/j.11-2166/r.2026.20.011.

摘要

目的

分析高尿酸血症（HUA）人群中医体质分布特点及患病相关因素，为HUA的个性化防治提供参考。

方法

采用横断面研究设计，纳入同时完成血尿酸检测和中医体质辨识的体检人群。根据血尿酸水平将研究对象分为高尿酸血症组与血尿酸正常组；根据体质辨识结果，将研究对象分为平和质、单一偏颇体质、兼夹体质。比较两组中医体质分布特点；将高尿酸血症组研究对象分别按性别及年龄（≥18岁且＜40岁、≥40岁）进行分层，比较不同性别及年龄组的中医体质分布特征；采用Logistic回归分析HUA患病的相关因素，并进一步开展性别和年龄分层分析。

结果

共纳入受试者10 920例，高尿酸血症组4170例（38.19%）、血尿酸正常组6750例（61.81%）；中医体质中平和质420例（3.85%）、单一偏颇体质6108例（55.93%）、兼夹体质4392例（40.22%）。高尿酸血症组中平和质人群80例（19.05%）；单一偏颇体质人群2275例（37.25%），以湿热质（1205例，52.97%）、痰湿质（500例，21.98%）和气郁质（181例，7.96%）占比较高；兼夹体质人群1815例（41.33%），其中痰湿质兼夹（51.35%，932例）、血瘀质兼夹（47.00%，853例）及湿热质兼夹（41.21%，748例）占比较高。Logistic回归显示，气郁质（OR=1.68）、气郁质兼夹（OR=1.53）、痰湿质兼夹（OR=1.55）及血瘀质兼夹（OR=1.50）为HUA独立相关因素（

＜0.05）。性别分层分析显示，痰湿质兼夹与女性HUA患病风险呈正相关；年龄分层分析显示，在≥18岁且＜40岁人群中，气郁质、气郁质兼夹及痰湿质兼夹与HUA患病风险呈正相关（均

＜0.05）。

结论

HUA患病存在显著性别及年龄差异，兼夹体质在HUA患者中占比更高，气郁质、气郁质兼夹、痰湿质兼夹及血瘀质兼夹是HUA的相关因素，其中痰湿质兼夹在女性中、气郁质在青年人群中的特异性关联尤为突出。

Abstract

Objective

To analyze the distribution characteristics of traditional Chinese medicine （TCM） constitution and factors associated with hyperuricemia （HUA） in the HUA population， providing a reference for persona-lized prevention and management of HUA.

Methods

A cross-sectional study was conducted among individuals who had completed both serum uric acid （SUA） testing and TCM constitution identification during health examinations. According to SUA levels， participants were divided into a hyperuricemia group and a normal SUA group； according to the constitution identification results， participants were classified into balanced constitution， single biased constitution， and mixed constitution. The distribution characteristics of TCM constitution were compared between the two groups； participants in the hyperuricemia group were stratified by sex and age （≥18 years and ＜40 years， ≥40 years）， and the distribution characteristics of TCM constitution were compared across different sex and age groups. Logistic regression was used to analyze factors associated with HUA， with further stratified analyses by sex and age.

Results

A total of 10 920 participants were included， comprising 4170 cases （38.19%） in the hyperuricemia group and 6750 cases （61.81%） in the normal serum uric acid group. According to TCM constitution， there were 420 cases （3.85%） with balanced constitution， 6108 cases （55.93%） with single biased constitution， and 4392 cases （40.22%） with mixed constitution. In the hyperuricemia group， there were 80 cases （19.05%） with balanced constitution； 2275 cases （37.25%） with single biased constitution， among which damp-heat constitution （1205 cases， 52.97%）， phlegm-dampness constitution （500 cases， 21.98%）， and

-stagnation constitution （181 cases， 7.96%） accounted for relatively high proportions； and 1815 cases （41.33%） with mixed constitution， among which mixed constitution involving phlegm-dampness （51.35%， 932 cases）， mixed constitution involving blood stasis （47.00%， 853 cases）， and mixed constitution involving damp-heat （41.21%， 748 cases） accounted for relatively high proportions. Logistic regression showed that

-stagnation constitution （OR=1.68）， mixed constitution involving

-stagnation （OR=1.53）， mixed constitution involving phlegm-dampness （OR=1.55）， and mixed constitution involving blood stasis （OR=1.50） were independently associated with HUA （

＜0.05）. Sex-stratified analysis showed that mixed constitution involving phlegm-dampness was positively associated with HUA risk in females； age-stratified analysis showed that， among individuals aged ≥18 and ＜40 years，

-stagnation constitution， mixed constitution involving

stagnation， and mixed constitution involving p

hlegm-dampness were positively associated with HUA risk （all

＜0.05）.

Conclusion

The prevalence of HUA differs markedly by sex and age. Mixed constitution accounts for a higher proportion of HUA patients.

-stagnation constitution， mixed constitution involving

stagnation， mixed constitution involving phlegm-dampness， and mixed constitution involving blood stasis are associated with HUA. Notably， the specific association of mixed constitution involving phlegm-dampness in females and

-stagnation constitution in young adults is particularly prominent.

关键词

Keywords

references

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