32 cases of grand mal seizure were pla-ced under clinical observation.In spite ofadequate treatment with antiepileptic drugs

the occurrence of seizures is at least 4 timesin the previous month in each case.32 caseswere treated then

in addition to the orig-inal medication with Qingyangsen（Root ofCynanchum otophyllum Schneid.）.After acourse treatment of 2-9 months

seizureswere fundamentally controlled in 9 cases.The reduction of seizure frequency in 20cases had been more than 50%

while thatin the other 3 cases

it had been less than50%.None became worse.No side effectwere observed during the course of treat-ment.Discussion on the dosage

route of admi-nistration and factors influencing the effi-cacy were given.The anticonvulsant activity of Qingyang-sen were examined by the“kindling”testin kindled rat models

comparing with theefficacy of phenobarbital.It was revealedthat Qingyangsen had anticonvulsant effecton experimental models of epilepsy.