The effect of electroacupuncture on thelevels of plasma cAMP and cGMP in ratswas observed preliminarily.When the ani-mals were fixed alone

the average valuesof their plasma cAMP and cGMP were el-evated significantly（P<0.05）

but the ave-rage value of cAMP/cGMP ratio was un-changed.However

the restrained animals werestimulated by appropriate electroacupuncture

their plasma cAMP levels were further el-evated（P<0.001）as compared with thefixed control group

while the cGMP wasnot influenced

thus the average value ofcAMP/cGMP ratio was increased（P<0.001）.The mechanism and the clinic implicationfor these phenomena were discussed briefly.It suggests that the increase in plasma cAMPafter acupuncture has relation to the func-tion of sympatho-adrenergic system and ad-renocortex

and in some conditions

the acu-puncture stimulation might possess a strongand healthy action.In addition

the relationship betweenacupuncture analgesia and the level of plas-ma cAMP was studied too.It is consideredthat a lower or higher level of plasma cA-MP after acupuncture appears to have no re-lation to acupuncture analgesia

but may beas a result of good or poor effect of acupun-cture analgesia.