Actions of Shanhaidan V on Experimental Myocardial Ischemia in Rads[J]. Journal of Traditional Chinese Medicine1995, (11): 689-690.DOI: 10.13288/j.11-2166/r.1995.11.035.
To rat model of myocardial ischemia induced by liga-tion of coronary artery. Shanhaidan V was given via duodenum 15 minutes after ligation. ECG and quantitative measurement of the area of infarction by N -BT staining 3 hours after ligation were performed before and after drug administration. Results showed’ that the heart beat rates 15. 45. 65. 105. 165 minutes after administration of Shanhaidan V were slowed down (P<0. 05 - 0. 01). ST segment in all groups markedly elevated 15 minutes after ligation. When Shanhaidan V was given in 1. 4. 2. 8 g/kg dose
ST segment markedly lowered (P<0. 01).
Shanhaidan V : (0. 7
1. 4. 2. 8 g/kg) also decreased the area of infarction (P<0..01). Conclusion: Shanhaidan V ameliorated the degree of ischemia
in rat’s ischemic cardiac muscle; reduced the infarct area and slowed down rate . of heart beat.