By adopting fluorescence testing method

we observed the contents of central and peripheral 5 - HT

nerve transmitter and its metabolites in reserpinized hypos-plenic function rats by different qualities and quantities of moxibustion. Results showed that in experimental hyposplenic function rats

there was a marked lowering of contents of central .and peripheral 5 -HT （P< 0. 05）. Moxibustion on Zusanli point greatly increased its contents. When strong stimulus was administered

5-HT contents in cerebral contex markedly increased （P<0. 05）

while weak stimulus markedly increased that in peripheral blood （P<0. 05）. Stimulation with cigarette didn"t yield such results

suggesting the superior action of moxibustion to cigarette. The strength of action was related to the amount and intensity of stimulation.