The experiment was conducted in rats with CIA on which wind - cold - dampness

wind - heat -dampness stimulation and topical rubbing of SEB were given. Results showed that

wind - cold- dampness or wind - heat - dampness alone didn’t increase the incidence of CIA and integration of inflammation

norchange the surface temperature of the affected joint. However

wind -heat -dampness markedly increased the content of 99mTc of affected joint in female rats. When SEC was rubbed on the surface

wind -cold -dampness markedly increases the integration of inflammation in male rats （as compared with pure SEB）. and markedly increased the DTH reaction of male rats （as compared with wind -heat- dampness） . Whereas wind - heat dampness markedly increased the content of 99mTc of affected joints in female rats （ as compared with wind - cold - dampness） when topically applied SEB. wind - heat - dampness markedly increased the surface temperature of affected joint in female rats

while wind- heat - dampness and wind - cold - dampness markedly lowered that in the male rats.