One - hundred twenty - three cases of schizophrenia were classified as the following types: inner disturbance by phlegmatic fire （ IDPF）

exuberant fire due to yin-depletion （ EFYD）

inner obstruction of phlegmatic dampness （IOPD） and Yang depletion （YD）. Sixty - six cases were treated as integrated Chinese and western medicine group （66 cases） and western drug group （57 cases）. Observation by dose- score table analysis and 3- year following exam all showed that the results of integrated group was superior to the western drug group. The contents of β- EP in IOPD and YD types were increased from sub- normal level after therapy. The contents of NT in IDPF group was dropped to normal after treatment; while that in the other 3 groups were all distinctively increased

demonstrating that there was biochemical basis for the treatment based on syndrome typing.