Prevention and Treatment of Re -stenosis after PTA in Rabbit with Xuefu Zhuyu Concentrated Pills[J]. Journal of Traditional Chinese Medicine1997, (11): 685-687.
Prevention and Treatment of Re -stenosis after PTA in Rabbit with Xuefu Zhuyu Concentrated Pills[J]. Journal of Traditional Chinese Medicine1997, (11): 685-687.DOI: 10.13288/j.11-2166/r.1997.11.028.
Rabbit model of arteriosckrosis of iliac artery was used in this experiment. Results showed: after 4 weeks of PTA operation
the calibre of the artery in large dose concentrated pill (LCP) group was obviously larger than that of the western drug group and Lovastatin group (P<0. 01 andP<0. 001). For the rate of restenosis at the site of vessel lesion
the LCP group was obviously lower than that of the blank control group (P<0. 005). For the thickness of iliac arterial intima
the LCP group was markedly smaller that of the Lovastatin and blank control groups (P<0. 01-P < 0. 001). By transmission electro - microscopic observation
the organelle in the vascular smooth muscle cells in LCP and small - duo group contained myofilaments well differentiated
while those in the Lovastatin and blank control groups were much more and in proliferated condition. The level of blood lipids in all 4 groups A weeks after PTA operation showed no significant difference.