Objective: To approach to correlativity of levels of sexual hormones with coronary heart disease （ CHD ） of postmenopausal women and metabolism of blood Hpids

and effects of tonifying the liver and kidney method. Methods: 60 postmenopausal women with CHD were randomly divided into Chinese drug group and western drug group

30 cases each group. They were respectively treated with tonifying the liver and kidney method and Nylestriol for 6 monthes

and 30 health subjects were used as control group

and their blood estradiol （E2）

total cholesterol （TC） and low density lipoprotein -cholesterol （LDL - C） levels were determined before treatment and 3

6 months after treatment. Results: （1） E2 level in the CHD group was significantly lower than that of the control group （P<0. 01） : （2） E2 level increased gradually （P<0. 01）. and LDL - C and TC levels decreased significantly （P<0. 05） after treatment for 6 months in the Chinese drug group. with no significant difference as compared with the western drug group （P > 0. 05）; （3） E2 level increased and TC level decreased after treatment for 6 months in the Chinese drug group

the both showed a significantly negative correlation （r1 = - 0. 905

P < 0. 01） ; E2 and LDL levels also showed significantly negative correlation （rl = - 0. 909. P<0. 01;r2 = - 0. 912. P<0. 01）. Conclusion: Attack of postmenopauseal female CHD is related with decrease of female hormone levels. Tonifying the liver and kidney therapy is good for protecting the heart and blood vessels

and it is one of effective methods for prevention and treatment of postmenopausal female CHD-