To observe clinical therapeutic effect of Ren Zhu Jian Wei Granules on precancerous lesion of stomach. Methods: 130 cases of precancerous lesion of stomach were randomly divided into tow groups

the treatment group （88 cases） treated with Ren Zhu Jian Wei capsules and the control group （42 cases） treated with Wei Fu Chun Tablets

and clinical data were analyzed. Results: The comprehensive therapeutic effect was 92. 0% in the treatment group and 73. 8% in the control group; and the clinical therapeutic effect was 94. 3% in the treatment group and 78. 6% in the control group with a significant difference （P<0. 01）. The effective rate for gastroscopy was 73. 9% in the treatment group and 59. 5% in the control group; 79. 5% for gastric atrophy in the treatment group and 59. 5% in the control group; 80. 8% for intestinal metaplasia in the treatment group and 62. 5% in the control group with significant difference between the two groups （P < 0. 01 or P < 0. 05）. improving rate for helicobacter pylori （HP） infection was 65. 4 % in the treatment group and 48. 3% in the control group. Conclusion: Ren Zhu Jian Wei Granules exerts therapeutic action through improving HP infection and blood circulation of gastric mucosa.