Objective: To objectively assess the therapeutic effect and safety of Yi Shen Zhuang Gu Mixture. Methods: 160 cases of osteoporosis were observed. Among them

the treatment group （96 cases） were treated with Yi Shen Zhuang Gu Mixture and the control group （32 cases） were treated with Shen Gu Capsules and 32 cases of osteoporosis who had not taken any medicines in a half year were used as blank group. Bone density

clinical symptoms

osteocalcin

urinary pyridol

estrodiol

testosterone

urea nitrogen

transaminase. calcium

phosphorus

alkaline phosphatase

urine routine examinations were investigated. Results: The comprehensive therapeutic effect in the treatment group was better than that in the control group. Conclusion: Yi Shen Zhuang Gu Mixture can increase bone density

promote formation of bone and inhibit absorption of bone

and it is safe and reliable to treat osteoporosis.