Objective: To explore experimental methods for damp-heat quantification in damp-heat syndrome of epidemic febrile disease and scan highly correlative quantification indexes. Methods: AQP2. endothenin （ET ）. calcitonin-gene related peptide（CGRP） and granulocyte colony stimulating factor （G-CSF） . middle molecular substance （MMS） and hydrosulfide substances（R-SH） were determined in the damp-heat animal model. Results: AQP2 level in damp-heat model group was significantly lower than that in normal control group

and after treatment by Qingxiang Powder it was restored basically to the normal level. ET level in damp-heat model group was higher and CGRP was lower than that in normal group （P<0. 01） . Blood G-CSF and MMS increased and R-SH level decreased in the damp-heat rats. After treatment of one week by Qingxiang Powder

blood G-CSF. MMS and R-SH basically restored to normal

and G-CSF positive rate increased in model control group. Conclusion: AQP2 ET. CGRP. G-CSF. R-SH and MMS can be respectively used as correlative quantification indexes for the patient with "more dampness" . "more heat" and "the cause of disease of damp-heat".