仙杞煎液对实验性骨质疏松大鼠骨密度、白介素6和血浆酸性磷酸酶的影响

张丽君; 张艳; 徐谦; 刘莉; 黄虹

doi:10.13288/j.11-2166/r.2003.10.041

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仙杞煎液对实验性骨质疏松大鼠骨密度、白介素6和血浆酸性磷酸酶的影响

更新时间：2021-11-22

- 仙杞煎液对实验性骨质疏松大鼠骨密度、白介素6和血浆酸性磷酸酶的影响
- Effect of Xianqi Decoction on bone mass density. IL-6 and plasma acid phosphatase in experimental osteoporosis rats
- 中医杂志 2003年第10期页码：780-781
- 作者机构：
  
  1. 湖北中医学院附属门诊部
  2. 湖北中医学院附属门诊部湖北省武汉市武昌区中山路364号,430061
- 作者简介：
- 基金信息：
  
  湖北省高等学校科学研究青年发展项目基金（98B022）
- DOI：10.13288/j.11-2166/r.2003.10.041
  中图分类号： R285
- 纸质出版：2003
- 稿件说明：
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[1]张丽君,张艳,徐谦,刘莉,黄虹.仙杞煎液对实验性骨质疏松大鼠骨密度、白介素6和血浆酸性磷酸酶的影响[J].中医杂志,2003(10):780-781+5.

Effect of Xianqi Decoction on bone mass density. IL-6 and plasma acid phosphatase in experimental osteoporosis rats[J]. Journal of Traditional Chinese Medicine2003, (10): 780-781.
[1]张丽君,张艳,徐谦,刘莉,黄虹.仙杞煎液对实验性骨质疏松大鼠骨密度、白介素6和血浆酸性磷酸酶的影响[J].中医杂志,2003(10):780-781+5. DOI： 10.13288/j.11-2166/r.2003.10.041.

Effect of Xianqi Decoction on bone mass density. IL-6 and plasma acid phosphatase in experimental osteoporosis rats[J]. Journal of Traditional Chinese Medicine2003, (10): 780-781. DOI： 10.13288/j.11-2166/r.2003.10.041.

摘要

目的:探讨仙杞煎液对大鼠实验性骨质疏松症的治疗作用及其作用机理。方法:选用7月龄SD雌性大鼠72只

随机分为2组。手术组60只行双侧卵巢切除术

假手术组12只行伪手术

复制成绝经后骨质疏松大鼠模型。将手术组随机分为模型组、西药组、仙杞煎液低、中、高剂量组

连同假手术组共6组按相应剂量灌胃给药。60天后摘眼球取血后将大鼠处死。分离血清和血浆

测定血清白细胞介素6（IL-6）和血浆酸性磷酸酶（ACP）水平

测大鼠脊柱和股骨骨密度。结果:与模型组相比

各中药组可显著降低IL-6和PCP水平（P<0.05或P<0.01）.中药各剂量组及西药组间差异无显著性（P>0.05）。与模型组相比

各用药组骨密度均升高（P<0.05）。

Abstract

Objective: To investigate the effect of Xianqi Decoction on experimental osteoporosis of rats and its mechanism. Methods: 72 female SD rats aged 7 months were randomly divided into two groups

i. e. 60 for operation group

12 for sham-operation group. Bilateral ovariectomy was performed on operation group. 2 months later

postmenopausal osteoporosis model rats were successfully established. Rats in operation group were randomly divided into model group

western medicine group

Xianqi Decoction low dose group

middle dose group and high dose group. Total six groups were given corresponding medicine by intragastric perfusion. 60 days later

rats were sacrificed after taking blood sample. Serum IL-6. plasma acid phosphatase （ACP） and bone mass density of vertebra and femur were determined. Results: Compared with model group. IL-6 and ACP level in three Xianqi Decoction groups was significantly reduced （P<0. 05 or P<0. 01）. and there was no significant difference among Xianqi Decoction groups and western medicine group. Bone mass density in all drug-administered groups was increased （P<0. 05）.

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