To explore changes of serum extracellular matrixes and adhesion molecule and Tongsai Granules on them in the patient of senile chronic obstructive pulmonary disease （COPD） at acute exacerbation stage. Methods: 56 cases of COPD at exacerbation stage were divided into treatment group and control group. The treatment group was treated by oral administration of Tongsai Granules on the basis of the same treatment for the control group. Serum levels of extracellular matrixes components and adhesion molecule before and after treatment were detected

and 20 healthy old people were taken as comparison. Results: Serum levels of collagen type Ⅰ （C Ⅰ）. collagen type Ⅲ（C Ⅲ ） and collagen type Ⅳ （C Ⅳ ）

soluble intracellular adhesion molecular-1 （1CAM-1）

E-selectin in the patient of COPD at the exacerbation stage were significantly higher than those in the healthy old people （P<0. 01）. After treatment

serum levels of C Ⅰ . CⅢ

C Ⅳ . ICAM-1 and E-selectin in the treatment group and C Ⅲ level in the control group were significantly decreased （P <0. 01 or P<0. 05）. The decreases of the above indexes in the treatment group were more significant than those in the control group （P < 0. 01）. Conclusion: Extracellular matrixes and adhesion molecule are involved in the pathological process of senile COPD at the acute exacerbation stage

and decreases of extracellular mixtrixes and adhesion molecule induced by Chinese herbs Tongsai Granules is possibly one of the main mechanisms of the recipe for treatment of senile COPD.