Objective: To observe effects of Ganzhikang Capsule on ultrastructures in non-alcoholic fatty liver model rats so as to provide morphological basis for clinical treatment. Methods: Fatty liver model rats were induced by high fat diet

and the effects of Ganzhikang Capsule on microstructures in liver tissue were investigated with Dong Bao Gan Tai used as control medicine. Results: In the model group

serious fatty degeneration of hepatocytes with inflammatory infiltration

degeneration and necrosis

and deforming

swelling of mitochondrion

dilatation of endoplasmic reticulum were found. After treatment of Ganzhikang Capsule

microstructures of hepatocytes restored obviously

fatty degeneration relieved significantly

and Ganzhikang Capsule was superior to Dong Bao Gan Tai in restoration of fatty degeneration （P < 0. 05）. Conclusion: Ganzhikang Capsule is effective for non-alcoholic fatty liver.