Wang Dongsheng~1, Yuan Zhaokai~2, Huang Xianping~2, et al. Effect of Yangxin Tongmai Tablet on Apoptosis of Pathological Cells in the Rat of Atherosclerosis with Phlegm Stasis[J]. Journal of Traditional Chinese Medicine2004, (12): 937-940.
Wang Dongsheng~1, Yuan Zhaokai~2, Huang Xianping~2, et al. Effect of Yangxin Tongmai Tablet on Apoptosis of Pathological Cells in the Rat of Atherosclerosis with Phlegm Stasis[J]. Journal of Traditional Chinese Medicine2004, (12): 937-940.DOI: 10.13288/j.11-2166/r.2004.12.031.
Objective: To observe the effect of Yangxin Tongmai Tablet on apoptosis of pathological cells in the rat of atherosclerosis (AS) with phlegm stasis. Methods: Atherosclerosis rat model was developed by high fat gorage. Formation of arterial plaques was detected one month after modeling as index of successful modeling. The treatment group was treated by Yangxin Tongmai Tablet and the control group with Jiao Gu Lan Zhong Dai Tablet for one month and then changes of blood lipid
blood sugar
hemorheological indexes
insulin
apoptosis of arterial vascular smooth muscular cells(VSMC) were observed. Results: Yangxin Tongmai Tablet could significantly decrease blood lipid
improve hemorheological indexes and insulin resistance
remove plagues and maintain structures and functions of the aorta
and make apoptosis tend to normal. Conclusion: Yangxin Tongmai Tablet has a good effect in improving apoptosis of pathological cells in the rat of AS with phlegm stasis.