健脾理气方联合介入疗法治疗肝癌远处转移25例临床观察

林钧华; 郭伟剑

doi:10.13288/j.11-2166/r.2005.01.015

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健脾理气方联合介入疗法治疗肝癌远处转移25例临床观察

更新时间：2021-11-20

- 健脾理气方联合介入疗法治疗肝癌远处转移25例临床观察
- Clinical Observation on Jianpi Liqi Recipe for Treatment of 25 Cases of Distal Metastasis of Liver Cancer
- 中医杂志 2005年第1期页码：26-28
- 作者机构：
  
  1. 上海复旦大学肿瘤医院中医科
  2. 上海第二医科大学新华医院肿瘤科上海市东安路270号,200032
  3. 上海复旦大学肿瘤医院中医科上海第二医科大学新华医院肿瘤科上海市东安路270号,200032
- 作者简介：
- 基金信息：
  
  上海市卫生局中医药科研基金课题（00—P—13）
- DOI：10.13288/j.11-2166/r.2005.01.015
  中图分类号： R735.7
- 纸质出版：2005
- 稿件说明：
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[1]林钧华,郭伟剑.健脾理气方联合介入疗法治疗肝癌远处转移25例临床观察[J].中医杂志,2005(01):26-28.

Clinical Observation on Jianpi Liqi Recipe for Treatment of 25 Cases of Distal Metastasis of Liver Cancer[J]. Journal of Traditional Chinese Medicine2005, (1): 26-28.
[1]林钧华,郭伟剑.健脾理气方联合介入疗法治疗肝癌远处转移25例临床观察[J].中医杂志,2005(01):26-28. DOI： 10.13288/j.11-2166/r.2005.01.015.

Clinical Observation on Jianpi Liqi Recipe for Treatment of 25 Cases of Distal Metastasis of Liver Cancer[J]. Journal of Traditional Chinese Medicine2005, (1): 26-28. DOI： 10.13288/j.11-2166/r.2005.01.015.

摘要

目的:观察健脾理气中药对肝癌肝动脉化疗栓塞（TACE）促转移的干预作用。方法:50例原发性肝癌随机分为 TACE组和 TACE+健脾理气方组

于 TACE 前后测定血清血管内皮细胞生长因子（VEGF）水平

观察生存率和远处转移率。结果:TACE 治疗前后及两组间 VEGF 差异无显著性（P>0.05）

TACE 组1、2年生存率分别为76%、40%

TACE+健脾理气方组1、2年生存率分别为72%、64%

两组2年生存率差异有显著性（P<0.01）。两组1、2年远处转移率分别为28%、52%和8%、24%

2年远处转移率差异有显著性（P<0.05）。结论:健脾理气中药对 TACE 促肝癌转移有一定的阻断作用

但 TACE 后短期内并未明显抑制 VEGF 的表达。

Abstract

Objective:To observe interfering action of Chinese drugs for strengthening spleen and regulating Qi on promoting metastasis of transcatheter arterial chemoemboization（TACE）of liver cancer.Methods:50 cases of primary cancer of liver were randomly divided into TACE group and TACE plus Jianpi Liqi Recipe group

and serum vascular endothelial growth factor（VEGF）level before and after TACE was determined and the survival rate and the distal metastasis rate were observed.Results:There was no significant differences before and after TACE

and between the two groups（P>0.05）.The survival rates of 1 and 2 years were 76%and 40% in TACE group

and 72% and 64% in TACE plus Jianpi Liqi Recipe group

respectively.There was a significant difference between the two groups in the survival rate of 2 years（P<0.01）.The distal metastasis rates of 1 and 2 years were 28%

52%

and 8%

24% in the two groups with a significant difference in the distal metastasis of 2 years between the two groups（P<0.05）.Conclusion:The drug for strengthening spleen and regulating Qi has a certain blocking action on TACE promoting metastasis of liver cancer

but TACE does not obviously inhibit depression of VEGF within a sort term.

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