Objective:To observe clinical

therapeutic effect of Qiankun Capsule on lung cancer and to study on the mechanism.Methods:100 cases of lung cancer were randomly divided into Qiankun Capsule group（capsule group）

chemotherapy group and chemotherapy plus capsule group（combination group）.Their clinical symptoms

immune indexes

blood picture

life state（assessed with Karnofsky criteria）

body weight

and expression of p53 protein and proliferating cell nuclear antigen（PCNA）were compared. Results:The total effective rate of 94.12% in the capsule group and 90.91% in the combination group were significantly higher than 57.58% in the chemotherapy group（P<0.01 or P<0.05）

indicating that Qiankun Capsule can significantly improve symptoms

increase body weight

effectively enhance quality of life

raise cellular immune function

decrease number of p53 and PCNA positive cells in the patient of lung cancer.Conclusion:Qiankun Capsule has a definite therapeutic effect

which is related with regulation of immune function and inhibition of expression of p53 and PCNA.