Objective:To observe therapeutic effect of Chinese drugs Yikang Decoction on male immune infertility.Methods:100 cases of male immune infertility were treated with Yikang Decoction（treatment group）and other 100 cases with prednisone as controls. Analysis of seminal fluid

detection of anti-sperm antihody（AsAb）and mycoplasma in serum and seminal plasma

and culture of mycoplasma

routine examination of prostate gland and physical examination were carried out.Results:（1）After treatment

AsAb level in serum and seminal plasma increased significantly in the two groups（P<0.01）

with more significant increase in the treatment group.（2）After treatment

the sperm density and percentage of motile spermatozoa increased significantly（P<0.01）in the two groups

with more increase in the treatment group.The pregnancy rate of their wives in the treatment group was higher than that in the control group（P<0.01）.（3）After treatment

the sperm agglutination rate in the two groups decreased significantly

with more significant decrease in the treatment group.（4）The improving rate of symptoms and the stability of therapeutic effect after ceasing of drugs in the treatment group was better than that in the control group（P<0.01）.Conclusion: Therapeutic effect of Yikang Decoction on male immune infertility is better than that of prednisone

with stable therapeutic effect.