Effects of Kuanxiongdan on Serum Superoxide Dismutase and others in the Rabbit of atherosclerosis[J]. Journal of Traditional Chinese Medicine2005, (2): 136-138.
Effects of Kuanxiongdan on Serum Superoxide Dismutase and others in the Rabbit of atherosclerosis[J]. Journal of Traditional Chinese Medicine2005, (2): 136-138.DOI: 10.13288/j.11-2166/r.2005.02.029.
Objective:To observe effects of Kuanxiongdan on SOD
LPO and oxLDL in rabbits of atherosclerosis.Methods:40 New Zealand rabbits were randomly divided into 5 groups
normal group
model group
large dose Kuanxiongdan group
small dose Kuanxiongdan group and Duoxikang Control group
and they were fed respectively with different forages for forty days.Serum SOD activity and LPO and oxLDL contents were determined.Results:In the model group SOD activity decreased and LPO and oxLDL increased significantly as compared with the normal group(P<0.05);SOD activity significantly increased and LPO and oxLDL increased in both the large dose Kuanxiongdan group and the small dose Kuanxiondan group as compared with those in the model group and the Duoxikang group(both P<0.05).Conclusion:Increase of SOD activity and decreases of LPO and oxLDL contents are possibly one of the mechanisms of Kuanxiongdan in alleviating atherosclerosis degrees and preventing and treating coronary heart disease.