Effect of Baihe Instant Granules on NF-κB of Vascular Endothelial Cells Activated by TNF-α[J]. Journal of Traditional Chinese Medicine2005, (4): 297-299.
Effect of Baihe Instant Granules on NF-κB of Vascular Endothelial Cells Activated by TNF-α[J]. Journal of Traditional Chinese Medicine2005, (4): 297-299.DOI: 10.13288/j.11-2166/r.2005.04.029.
Objective:To study on effects of Baihe Instant Granules on NF-kB activation and intercellular adhesion molecule-1(ICAM-1) expression of human umbilical cord vein endothelial cells(HUVEC)to explore the mechanism of Baihe Instant Granules for treatment of vasculitis.Methods:Nuclear factor-kB(NF-kB)aetivation and ICAM-1 expression of HUVEC were detected with cellular ELISA and indirect immunofluorescence staining method.Results:Baihe Instant Granules could inhibit activation of NF- kB stimulated by tumor necrosis factor-α(TNF-α)and ICAM-1 expression in HUVEC.Conclusion:Baihe Instant Granules play important therapeutic action on vasculitis possibly by inhibiting NF-kB activation to effectively regulate ICAM-1 expression which is closely related with inflammatory course.