Objective:To observe effects of Yangxin Tongmai Tablet on correlative indexes of insulin resistance syndrome.Methods:67 cases of insulin resistance syndrome were randomly divided into treatment group（Yangxin Tongmai Tablet group

n=33）and control group（dimethyldiguanide group

n=34）.They were treated for 8 weeks.Changes of blood glucose（FPG）

insulin（FINS）

insulin sensitive index（ISI）

insulin resistance index（IRI）

islet β cell function index（HBCI）

serum total cholesterol（TC）

serum triglyceride（TG）

high density lipoprotein-cholesterol（HDL-C）

low density lipoprotein-cholesterol（LDL-C）

systolic pressure （SBP）

diastolic pressure（DBP）and body mass index（BMI）before and after treatment were observed.Results:After treatment

FPG

FINS

IRI

TC

TG

LDL-C

SBP

DBP

BMI and clinical symptom scores decreased

and ISI and HDL-C increased significantly in two groups（P<0.05 or P<0.01）;while the treatment group in increasing HBCI and decreasing TG was superior to the control group.Conclusion:Yangxin Tongmai Tablet can effectively improve insulin resistance

increase islet β-cell function

promote tissues up-taking and using glucose and improve metabolism of lipids.