养阴清热煎剂对系统性红斑狼疮患者黏附分子表达及狼疮损伤指数的影响

陈爱平; 熊佩华; 李福民; 张玲; 府剑英; 潘肇荣; 李卫芳; 宋志刚; 詹玲琪; 朱方石; 金石

doi:10.13288/j.11-2166/r.2005.06.024

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养阴清热煎剂对系统性红斑狼疮患者黏附分子表达及狼疮损伤指数的影响

更新时间：2021-11-20

- 养阴清热煎剂对系统性红斑狼疮患者黏附分子表达及狼疮损伤指数的影响
- Effects of Yangyin Qingre Decoction on Expression of Adhesion Molecular and Lupus Index in the Patient of Systematic Lupus Erythematosus
- 中医杂志 2005年第6期页码：433-435
- 作者机构：
  
  1. 苏州大学附属第一医院中西医结合科
  2. 扬州大学医学院
  3. 南京中医药大学江苏省苏州市十梓街96号,215006
- 作者简介：
- 基金信息：
  
  2001年江苏省中医药管理局资助项目（H—032）
- DOI：10.13288/j.11-2166/r.2005.06.024
  中图分类号： R259
- 纸质出版：2005
- 稿件说明：
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[1]陈爱平,熊佩华,李福民,张玲,府剑英,潘肇荣,李卫芳,宋志刚,詹玲琪,朱方石,金石.养阴清热煎剂对系统性红斑狼疮患者黏附分子表达及狼疮损伤指数的影响[J].中医杂志,2005(06):433-435.

Chen Aiping Xiong Peihua Li Fumin. Effects of Yangyin Qingre Decoction on Expression of Adhesion Molecular and Lupus Index in the Patient of Systematic Lupus Erythematosus[J]. Journal of Traditional Chinese Medicine2005, (6): 433-435.
[1]陈爱平,熊佩华,李福民,张玲,府剑英,潘肇荣,李卫芳,宋志刚,詹玲琪,朱方石,金石.养阴清热煎剂对系统性红斑狼疮患者黏附分子表达及狼疮损伤指数的影响[J].中医杂志,2005(06):433-435. DOI： 10.13288/j.11-2166/r.2005.06.024.

Chen Aiping Xiong Peihua Li Fumin. Effects of Yangyin Qingre Decoction on Expression of Adhesion Molecular and Lupus Index in the Patient of Systematic Lupus Erythematosus[J]. Journal of Traditional Chinese Medicine2005, (6): 433-435. DOI： 10.13288/j.11-2166/r.2005.06.024.

摘要

目的:研究中医药对系统性红斑狼疮（SLE）的治疗作用机制及其对 SLE 器官损害的远期疗效。方法:1999～2003年住院及门诊的 SLE 患者51例

随机分为以中药养阴清热煎剂为主的中西医结合治疗组（简称治疗组）和单纯西药治疗的对照组（简称对照组）

进行了治疗前后血清细胞黏附分子1（ICAM-1）、黏附分子3（ICAM-3）、P-选择素以及 SLE 损伤指数（SLICC/ACRDI）的研究。结果:SLE 患者的 ICAM-1、ICAM-3、P-选择素均较正常人明显增高;治疗组治疗后 ICAM-1、P-选择素比对照组明显下降;而 SLE 损伤指数积分显示

治疗组比较稳定

对照组较治疗前有明显增加。结论:提示以中药养阴清热煎剂为主的治疗组对 SLE 患者的血清黏附分子高表达有明显的抑制作用

并对 SLE 的器官损害有明显的保护与修复作用。

Abstract

Objective:To study on the mechanism of Chinese medicine in treatment of systematic lupus erythematosus（SLE）and to observe long-term therapeutic effect of Chinese medicine on damage of organs in SLE.Methods:51 cases in-patients and out-patients of SLE from 1999 to 2003 were randomly divided into a treatment group treated with integrated Chinese medicine and western medicine and a control group treated with simple western medicine.Serum intracellular adhesion molecule-1（ICAM-1）

adhesion molecule-3（ICAM-3）

P-selectin and SLE injury index（SLICC/ACRDI）before and after treatment were observed.Results: ICAM-1

ICAM-3 and P-selectin in the patient of SLE were significantly increased as compared with those in normal persons. After treatment

ICAM-1 and P-seleetin in the treatment group decreased significantly as compared with those control group.The cumulative score of SLE injury index in treatment group was more stable and increased significantly in control group compared with that before treatment.Conclusion:The integrated treatment of Chinese medicine and western medicine with Yangyin Qingre Decoction has significant inhibiting action on the high expression of serum adhension molecule and has significant protective and repairing actions on the injury of organs in the patient of SLE.

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