Objective:To compare therapeutic effects of Chinese medicine prescriptions for nourishing Yin to purge pathogenic fire

and prescriptions for relieving the depressed liver in treatment of sexual precocity of girls.Methods:The girls with sexual precocity were divided with random

double blind and control methods into a treatment group treated with the prescription for nourishing Yin to purge pathogenic fire

Zaoshu No.Ⅱ

and a control group treated with the prescription for relieving the depressed liver

Xiaoyao Pill.The medicines were given with double blind and double simulated methods.The mammary nucleus index

mammary Tanner phasing

cumulative scores of TCM syndromes

B type ultrasonography（volume of the uterus

ovary

the biggest follicle diameter）

change of bone age were followed up and compared before and after treatment in the two groups.Follow-up was completed in 132 cases.Results:The treatment group in the mammary nucleus index

mammary Tanner phasing

decrease of cumulative scores of TCM syndromes after treatment was better than the control group（P<0.05 or P<0.01）;volume of the uterus

volume of ovary and follicle size in the treatment group were better than in the control group（P<0.01）.There was no significant difference between the two groups in change of bone age（P>0.05）.Conclusion:Chinese medicine for nourishing Yin to purge pathogenic fire

Zaoshu No.Ⅱ

in therapeutic effect for treatment of sexual precocity of girls is better than the Chinese medicine for relieving the depressed liver

Xiaoyao Pill.