Objective:To investigate the clinical effect of combined treatment of TCM and western medicine on serious hypothyroidism. Methods:40 cases of serious hypothyroidism were randomly divided into a treatment group of 22 and a control group of 18 cases. The treatment group were treated by thyroid hormone plus Chinese medicine for warming the kidney to promote diuresis.and the control group were treated by simple thyroid hormone.Improvement of main symptoms arid changes of thyroid functions were investigated.Results:The therapeutic effects of both groups were similar

the improvement of symptoms in the treatment group was significantly better than that in the control group

and the thyroid function increased in both groups（P

<

0.01）

with the treatment group significantly superior to the control group in improvement of T

3

（P

<

0.01）.Conclusion:Combined treatment of TCM and western medicine has a satisfactory therapeutic effect on serious hypothyroidism

and can rapidly improve symptoms. shorten therapeutic course and help recover thyroid function.