Objective:To probe essence of TCM syndrome of gastric carcinoma from gene protein expression.Methods:Based on the collected data from pre-operative patients of gastric carcinoma

their TCM syndromes were determined by means of TCM syndrome classification criteria.E-cadherin gene protein expressions in tumor tissue after operation of gastric cancer were detected with EnVision two step immunohistochemical method.Results:The expression rate of E-cadherin was 90% in 100 cases of gastric carcinoma

with significant difference among different syndrome types（P<0.01）.There was higher expression in the types of stagnation of phlegm-dampness

deficiency of both Qi and blood and deficiency-cold of the spleen and stomach

but with no significant difference among the 3 types;There was lower expression in the two types

stagnation of toxic substance in interior and incoordination of the liver and the stomach

with no significant difference between the two types.Conclusion:Metastasis of the two types

stagnation of toxic substance in interior and incoordination of the liver and the stomach

is possibly related with the lower expression of E-cadherin.